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Medical mycology

Comparative adherence of Candida albicans and Candida dubliniensis to human buccal epithelial cells and extracellular matrix proteins.


PMID 24625677

Abstract

Candida albicans and Candidaxa0dubliniensis are very closely related pathogenic yeast species. Despite their close relationship, C.xa0albicans is a far more successful colonizer and pathogen of humans. The purpose of this study was to determine if the disparity in the virulence of the two species is attributed to differences in their ability to adhere to human buccal epithelial cells (BECs) and/or extracellular matrix proteins. When grown overnight at 30°C in yeast extract peptone dextrose, genotype 1 C.xa0dubliniensis isolates were found to be significantly more adherent to human BECs than C.xa0albicans or C.xa0dubliniensis genotypes 2-4 (Pxa0