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Acta physiologica (Oxford, England)

Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance.


PMID 24703498

Abstract

To examine associations of DNA damage, cardiovascular risk factors and physical performance with vitality, in middle-aged men. We also sought to elucidate underlying factors of physical performance by comparing physical performance parameters to DNA damage parameters and cardiovascular risk factors. We studied 2487 participants from the Metropolit cohort of 11xa0532 men born in 1953 in the Copenhagen Metropolitan area. The vitality level was estimated using the SF-36 vitality scale. Cardiovascular risk factors were determined by body mass index (BMI), and haematological biochemistry tests obtained from non-fasting participants. DNA damage parameters were measured in peripheral blood mononuclear cells (PBMCs) from as many participants as possible from a representative subset of 207 participants. Vitality was inversely associated with spontaneous DNA breaks (measured by comet assay) (Pxa0=xa00.046) and BMI (Pxa0=xa00.002), and positively associated with all of the physical performance parameters (all Pxa0

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