EMAIL THIS PAGE TO A FRIEND

Fertility and sterility

Interleukin-25 induced by human chorionic gonadotropin promotes the proliferation of decidual stromal cells by activation of JNK and AKT signal pathways.


PMID 24746746

Abstract

To clarify the role and mechanism of interleukin (IL)-25 in regulating the biological functions of decidual stromal cells (DSCs) in human early pregnancy. Laboratory study of the effect of IL-25 induced by hCG on the proliferation of DSCs. Research laboratories. Women aged 23-47xa0years with normal pregnancy and abortion. None. Signal transduction from IL-25. Here we show that DSCs coexpress IL-25/IL-17RB. Human chorionic gonadotropin promotes the expression of IL-25/IL-17RB. In contrast to anti-human IL-25 neutralizing antibody, recombinant human IL-25 (rhIL-25) significantly stimulates the proliferation of DSCs in dosage- and time-dependent manners. RhIL-25 promotes the phosphorylation of AKT, extracellular-signal-regulated kinases 1/2 (ERK1/2), c-Jun N-terminal kinases (JNK), and nuclear factor κB in DSCs. Interestingly, blocking JNK or AKT signal with inhibitors down-regulates the stimulatory effect on DSC proliferation induced by rhIL-25. In addition, the results of Western blot show that the expression of IL-25/IL-17RB in DSCs from normal pregnancy was higher than that from abortion. Our results have revealed that hCG derived of trophoblasts up-regulates the expression of IL-25/IL-17RB in DSCs and that IL-25 further stimulates the proliferation of DSCs through activating JNK and AKT signals, which finally contributes to the establishment and maintenance of physiological pregnancy.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB4500797
Anti-AKT antibody produced in rabbit, affinity isolated antibody
SAB4500799
Anti-AKT antibody produced in rabbit, affinity isolated antibody
SAB4500800
Anti-AKT antibody produced in rabbit, affinity isolated antibody
SAB4500802
Anti-AKT antibody produced in rabbit, affinity isolated antibody
SAB4500803
Anti-AKT antibody produced in rabbit, affinity isolated antibody
SAB4300335
Anti-AKT1 (Ab-308) antibody produced in rabbit, affinity isolated antibody
SAB4300575
Anti-AKT1 (Ab-450) antibody produced in rabbit, affinity isolated antibody
SAB4300334
Anti-AKT1 (Ab-473) antibody produced in rabbit, affinity isolated antibody
GW22757 Anti-AKT1 (ab1) antibody produced in chicken, affinity isolated antibody, buffered aqueous solution
GW22775 Anti-AKT1 (ab2) antibody produced in chicken, affinity isolated antibody, buffered aqueous solution
SAB2501934
Anti-AKT1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution
SAB3500216
Anti-Akt1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
AV06008 Anti-AKT1 antibody produced in rabbit, affinity isolated antibody
SAB4500007
Anti-AKT1 antibody produced in rabbit, affinity isolated antibody
SAB4200176
Anti-JNK antibody, Mouse monoclonal, clone 1C2, purified from hybridoma cell culture
SAB4502398
Anti-JNK1 antibody produced in rabbit, affinity isolated antibody
SAB4300493
Anti-MAPK3 (Ab-202) antibody produced in rabbit, affinity isolated antibody
SAB4300494
Anti-MAPK3 (Ab-204) antibody produced in rabbit, affinity isolated antibody
GW22781 Anti-MAPK3 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution
SAB1412386
ANTI-MAPK3 antibody produced in mouse, clone 1E2, purified immunoglobulin, buffered aqueous solution
SAB2701851
Anti-mapk3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB2701770
Anti-mapk3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
HPA003995
Anti-MAPK3 antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
HPA005700
Anti-MAPK3 antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2104574
Anti-MAPK3 antibody produced in rabbit, affinity isolated antibody
SAB2104732
Anti-MAPK3 antibody produced in rabbit, affinity isolated antibody
SAB1406300
Anti-MAPK8 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
M3946 Anti-MNK1 antibody produced in rabbit, ~1.4 mg/mL, affinity isolated antibody, buffered aqueous solution
SAB4503422
Anti-MNK1 antibody produced in rabbit, affinity isolated antibody
SAB4503423
Anti-MNK1 antibody produced in rabbit, affinity isolated antibody