EMAIL THIS PAGE TO A FRIEND

Helicobacter

Characteristic epithelium with low-grade atypia appears on the surface of gastric cancer after successful Helicobacter pylori eradication therapy.


PMID 24766284

Abstract

The incidence of gastric cancer after successful Helicobacter pylori eradication has been increasing. We previously reported that epithelium with low-grade atypia (ELA) appeared on the surface of gastric cancer after H. pylori eradication. Here, we investigate the clinical and biological characteristics of such ELA. We studied 27 cases of gastric cancer detected after successful H. pylori eradication therapy. We examined the prevalence of ELA among these cases and its significance for endoscopic discovery after H. pylori eradication. We additionally investigated the mucus, p53 and Ki67 expressions in ELA. Epithelium with low-grade atypia that continuous with the gastric tumor was detected in 22 of 27 cases (81%), a significantly greater percentage than that for controls (p < 0.01). We found that gastric-type mucin was frequently expressed in this epithelium. Neither p53- nor Ki67-positive cells were found in ELA, irrespective of their expression in tumor tissue. The presence of ELA was positively correlated with the clinical interval between H. pylori eradication and gastric cancer detection. Epithelium with low-grade atypia on gastric cancer tissue, which may develop from gastric cancer cells, is frequently present after successful eradication therapy. This phenomenon could influence the practice of endoscopic diagnosis of gastric cancers.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB2500223
Anti-CDX2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution
AV31476
Anti-CDX2 antibody produced in rabbit, affinity isolated antibody
SAB3500187
Anti-CDX2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB1306667
ANTI-P53 (S15) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB1306713
ANTI-P53 (S315) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB1306623
ANTI-P53 (SUMOYLATION SITE SPECIFIC) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
P4235 Anti-p53 antibody produced in sheep, fractionated antiserum, buffered aqueous solution
SAB4300365
Anti-TP53 (Ab-18) antibody produced in rabbit, affinity isolated antibody
SAB4300369
Anti-TP53 (Ab-315) antibody produced in rabbit, affinity isolated antibody
SAB4300366
Anti-TP53 (Ab-33) antibody produced in rabbit, affinity isolated antibody
SAB4300367
Anti-TP53 (Ab-37) antibody produced in rabbit, affinity isolated antibody
SAB4300368
Anti-TP53 (Ab-46) antibody produced in rabbit, affinity isolated antibody
SAB4300362
Anti-TP53 (Ab-6) antibody produced in rabbit, affinity isolated antibody
SAB4300363
Anti-TP53 (Ab-9) antibody produced in rabbit, affinity isolated antibody
SAB2102511
Anti-TP53 (ab1) antibody produced in rabbit, affinity isolated antibody
SAB2102512
Anti-TP53 (ab2) antibody produced in rabbit, affinity isolated antibody
SAB2102513
Anti-TP53 (ab3) antibody produced in rabbit, affinity isolated antibody
SAB2102514
Anti-TP53 (ab4) antibody produced in rabbit, affinity isolated antibody
SAB2102515
Anti-TP53 (ab5) antibody produced in rabbit, affinity isolated antibody
SAB1406544
Anti-TP53 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
AV02055
Anti-TP53 antibody produced in rabbit, IgG fraction of antiserum
AV37163
Anti-TRP53 antibody produced in rabbit, IgG fraction of antiserum
SAB2106418
Anti-TRP53 antibody produced in rabbit, affinity isolated antibody
WH0001045M1
Monoclonal Anti-CDX2 antibody produced in mouse, clone 1C7, purified immunoglobulin, buffered aqueous solution
WH0004288M1
Monoclonal Anti-MKI67 antibody produced in mouse, clone 7B8, purified immunoglobulin, buffered aqueous solution
AMAB90870
Monoclonal Anti-MKI67 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL1234, purified immunoglobulin, buffered aqueous glycerol solution
SAB5300423 Monoclonal Anti-MKI67 antibody produced in mouse, clone 4A1, ascites fluid
SAB5300424 Monoclonal Anti-MKI67 antibody produced in mouse, clone 9C12B2, ascites fluid
SAB5300425 Monoclonal Anti-MKI67 antibody produced in mouse, clone 8D5, ascites fluid
P6749
Monoclonal Anti-p53 antibody produced in mouse, clone PAb1801, purified from hybridoma cell culture