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Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Inter- and intra-individual variation in urinary excretion of daidzein and equol in female Japanese.


PMID 24842557

Abstract

To evaluate the representativeness of single measurement of urinary soy-isoflavone concentrations for the assessment of long-term intake levels. Five urine samples taken from 14 Japanese female subjects over 2-3 months were measured for daidzein and equol by gas chromatography-mass spectrometry (GC-MS). Geometric mean daidzein and equol concentrations of 14 subjects were 582 and 2.66 μg/g creatinine, respectively. Intra-class correlation coefficients for daidzein and equol were 0.355 (95% CI: 0.130-0.649) and 0.741 (0.551-0.891), respectively. Single measurement of urinary equol is effective for the assessment of long-term equol status of Japanese subject while that of daidzein is not.