EMAIL THIS PAGE TO A FRIEND

Cancer letters

The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells.


PMID 24882622

Abstract

Hepatitis B X-interacting protein (HBXIP) is an important oncoprotein in hepatocarcinogenesis. Here, we found that the expression levels of HBXIP were positively associated with those of Secretogranin III (SCG3) in clinical hepatocellular carcinoma tissues. We identified that HBXIP up-regulated the expression of SCG3 through modulating both E2F transcription factor 1 (E2F1) and miR-509-3p. HBXIP suppressed miR-509-3p through activating NF-κB. In function, we showed that SCG3 increased the proliferation of hepatoma cells and HBXIP enhanced the proliferation of the cells via SCG3 in vitro and in vivo. Thus, we conclude that HBXIP facilitates the proliferation of hepatoma cells through up-regulating SCG3.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

AV04006
Anti-E2F1 (AB1) antibody produced in rabbit, affinity isolated antibody
HPA008003
Anti-E2F1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
E9026 Anti-E2F1 antibody produced in rabbit, ~0.8 mg/mL, affinity isolated antibody, buffered aqueous solution
SAB2103144
Anti-E2F1, (N-terminal) antibody produced in rabbit, affinity isolated antibody
SAB2101019
Anti-HBXIP antibody produced in rabbit, affinity isolated antibody
SAB1410105
Anti-HBXIP antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
HPA006812
Anti-LAMTOR5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
HPA006880
Anti-SCG3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2107389
Anti-SCG3 antibody produced in rabbit, affinity isolated antibody
SAB2107390
Anti-SCG3 antibody produced in rabbit, affinity isolated antibody
HPA007476
Anti-SGCG antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
AV44241
Anti-SGCG antibody produced in rabbit, IgG fraction of antiserum
SAB1411264
Anti-SGCG antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
PLA0139
Rabbit anti-E2F1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.