EMAIL THIS PAGE TO A FRIEND

Nature communications

The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.


PMID 24894631

Abstract

Accumulation of amyloid-β peptide (Aβ) in the brain underlies the pathogenesis of Alzheimer's disease (AD). Aβ is produced by β- and γ-secretase-mediated sequential proteolysis of amyloid-β precursor protein (APP). Here we identify a secretory protein named interleukin-like epithelial-mesenchymal transition inducer (ILEI, also known as FAM3 superfamily member C) as a negative regulator of Aβ production. ILEI destabilizes the β-secretase-cleaved APP carboxy-terminal fragment, the penultimate precursor of Aβ, by binding to the γ-secretase complex and interfering with its chaperone properties. Notch signalling and γ-secretase activity are not affected by ILEI. We also show neuronal expression of ILEI and its induction by transforming growth factor-β signalling. The level of secreted ILEI is markedly decreased in the brains of AD patients. Transgenic (Tg) overexpression of ILEI significantly reduces the brain Aβ burden and ameliorates the memory deficit in AD model mice. ILEI may be a plausible target for the development of disease-modifying therapies.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

AV50533
Anti-C1D (AB1) antibody produced in rabbit, affinity isolated antibody, lyophilized powder
AV50534
Anti-C1D (AB2) antibody produced in rabbit, affinity isolated antibody
HPA037588
Anti-C1D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
HPA037413
Anti-C1D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2701669
Anti-eno2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB1408571
Anti-ENO2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
SAB2101380
Anti-LRP1 (ab1) antibody produced in rabbit, affinity isolated antibody
SAB2101381
Anti-LRP1 (ab2) antibody produced in rabbit, affinity isolated antibody
L2295
Anti-LRP1 (N-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
HPA022903
Anti-LRP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
HPA004182
Anti-LRP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2101383
Anti-LRRC23 antibody produced in rabbit, affinity isolated antibody
HPA037766
Anti-LRRC23 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1305394
ANTI-NSE (Y236) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB1305395
ANTI-NSE (Y25) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB4300698
Anti-NSE antibody produced in rabbit, affinity isolated antibody
P5622
Anti-Pen-2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
PRS3979
Anti-PEN2 (ab1) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
PRS3981
Anti-PEN2 (ab2) antibody produced in rabbit, buffered aqueous solution
HPA047435 Anti-PSENEN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2107388
Anti-PSENEN antibody produced in rabbit, affinity isolated antibody