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Fundamental & clinical pharmacology

Comparison of the effects of clonidine, loperamide and metoclopramide in two models of gastric emptying in the rat.


PMID 24920467

Abstract

Several methods are used to evaluate gastric emptying (GE) in rats, which is an important endpoint in preclinical drug development. Although phenol red model or monitoring of plasma acetaminophen levels are well-established procedures for GE assessment, their capacity to detect the effects of pharmacological agents has rarely been compared. This study was therefore designed to evaluate clonidine with loperamide and metoclopramide in the two test models. Rats were administered phenol red or acetaminophen test meals. The remaining amount of phenol red in the stomach or the time course of plasma acetaminophen levels was then measured. In the phenol red test, loperamide (8xa0mg/kg, p.o.) and clonidine (100xa0μg/kg, s.c.) decreased GE (-88 and -42%, Pxa0