EMAIL THIS PAGE TO A FRIEND

FEBS letters

The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2.


PMID 24928441

Abstract

EZH2 is a key component of the polycomb PRC2 complex and functions as a histone H3 Lys27 (H3K27) trimethyltransferase. Here we show that EZH2 is down-regulated in human non-small cell lung cancer and low EZH2 expression predicts poor survival. Further we demonstrate that EZH2 inhibits lung cancer cell proliferation and colony formation in vitro and growth in vivo. We found that EZH2 binds to the promoter of Nrf2, where it increases H3K27me3 and represses Nrf2 expression. Finally, Nrf2 seems to be essential for the hyper proliferation of lung cancer cells in the absence of EZH2.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

E7031
Anti-EZH2 (N-terminal) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
SAB1405776
Anti-EZH2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
E6906
Anti-EZH2 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
AV38470
Anti-EZH2 antibody produced in rabbit, IgG fraction of antiserum, lyophilized powder
SAB2106436
Anti-EZH2 antibody produced in rabbit, affinity isolated antibody
SAB1410354
Anti-EZH2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
SAB4500348
Anti-Histone H3 (Acetyl-Lys14) antibody produced in rabbit, affinity isolated antibody
SAB4500349
Anti-Histone H3 (Acetyl-Lys18) antibody produced in rabbit, affinity isolated antibody
SAB4500350
Anti-Histone H3 (Acetyl-Lys23) antibody produced in rabbit, affinity isolated antibody
SAB4500351
Anti-Histone H3 (Acetyl-Lys27) antibody produced in rabbit, affinity isolated antibody
SAB4500347
Anti-Histone H3 (Acetyl-Lys9) antibody produced in rabbit, affinity isolated antibody
H9289
Anti-Histone H3 (N-terminal) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
H0164
Anti-Histone H3 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
SAB2501713
Anti-NFE2L2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution
HPA002990
Anti-NFE2L2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2701989
Anti-NFE2L2 antibody produced in rabbit
PLA0302
Goat anti-GAPDH Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.
SAB1408985 Monoclonal Anti-EZH2 antibody produced in mouse, clone 1D11, purified immunoglobulin, buffered aqueous solution
WH0004780M1
Monoclonal Anti-NFE2L2 antibody produced in mouse, clone 1F3, purified immunoglobulin, buffered aqueous solution
SAB1404123
Monoclonal Anti-NFE2L2 antibody produced in mouse, clone 2G7, purified immunoglobulin, buffered aqueous solution
SAB1409360
Monoclonal Anti-NFE2L2 antibody produced in mouse, clone 3G7, purified immunoglobulin, buffered aqueous solution
SAB1409361
Monoclonal Anti-NFE2L2 antibody produced in mouse, clone 2D5, purified immunoglobulin, buffered aqueous solution
SAB1409362
Monoclonal Anti-NFE2L2 antibody produced in mouse, clone 4C3, purified immunoglobulin, buffered aqueous solution
SAB1409363
Monoclonal Anti-NFE2L2 antibody produced in mouse, clone 1G10, purified immunoglobulin, buffered aqueous solution
PLA0148
Rabbit anti-Histone H3 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.