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The Journal of pharmacy and pharmacology

Inhibitory effects of Solanum tuberosum L. var. vitelotte extract on 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice.


PMID 24961480

Abstract

We aimed to investigate the inhibitory efficacy of Solanum tuberosum L. var. Vitelotte (SV) extract on atopic dermatitis (AD)-like skin lesions induced by the topical application of 2,4-dinitrochlorobenzene in NC/Nga mice. SV extract was administered orally to NC/Nga mice at the dose of 75, 150 or 300 mg/kg for 4 weeks. The effectiveness of SV extract in NC/Nga mice was evaluated by measuring symptom severity, ear thickness, scratching behaviour, serum levels of IgE, IgG1 and IgG2a, T helper 1 (Th1; interferon-γ and IL-12) and Th2 cytokines (IL-4 and IL-13) in spleen, messenger RNA (mRNA) expression of inflammatory cytokines and chemokines in tissue and infiltration of inflammatory cells in tissue. Oral administration of SV extract to NC/Nga mice resulted in the inhibition of the development of AD-like skin lesions. SV extract was attenuated AD-like skin lesion, ear thickening and scratching behaviour. SV extract also alleviated infiltrated inflammatory cells in tissue. Production of Th1 and Th2 cytokines was inhibited in splenocyte cultures. Additionally, reduced levels of IgE and IgG1/IgG2a ratio in serum and expression of AD-related mRNAs in lesional skins were observed in SV-treated mice compared with control group. SV extract alleviated the exacerbation of AD-like skin lesions in NC/Nga mice by suppressing total serum level of IgE and correcting the Th1/Th2 balance.