EMAIL THIS PAGE TO A FRIEND

The Annals of otology, rhinology, and laryngology

Oncologic efficacy of angiolytic KTP laser treatment of early glottic cancer.


PMID 24970297

Abstract

Angiolytic laser removal of early glottic cancer with ultra-narrow margins was reported in a pilot study 5 years ago as an innovative surgical treatment strategy to better preserve vocal function. Subsequently, in a cohort of > 90 patients, enhanced voice outcomes were achieved and there was diminished need for post-treatment phonosurgical reconstruction. However, the initial pilot study examining oncologic efficacy had a limited number of patients and most did not have 3-year follow-up. Consequently, further analysis of the oncologic efficacy is valuable. Retrospective review. One hundred seventeen patients (T1a-71, T1b-11, T2a-10, T2b-25) underwent potassium-titanyl-phosphate (KTP) laser treatment of early glottic cancer with a minimum 3-year follow-up (average = 53 months). The "b" designation delineated bilateral disease. Disease control for T1 and T2 lesions was 96% (79/82) and 80% (28/35), respectively. All 10 recurrences were treated with radiotherapy. Fifty percent (5/10) were controlled with radiotherapy, and the other 5 died of disease. Larynx preservation and survival were achieved in 99% (81/82) with T1 disease and 89% (31/35) with T2 disease. This investigation provides further evidence that angiolytic KTP laser removal of early glottic cancer with ultra-narrow margins is an effective oncologic treatment strategy. Radiotherapy was preserved for future use in more than 90% of patients. Since a majority of patients are referred by an otolaryngologist to undergo treatment of early glottic cancer with radiotherapy, this investigation provides compelling information to reappraise this paradigm.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

IRMM531A
Titanium, IRMM® certified Reference Material, 0.1 mm foil
Ti
IRMM531B
Titanium, IRMM® certified Reference Material, 0.5 mm foil
Ti
IRMM531C
Titanium, IRMM® certified Reference Material, 0.5 mm wire
Ti
305812
Titanium, crystalline, 5-10 mm, ≥99.99% trace metals basis (purity exclusive of Na and K content)
Ti
433667
Titanium, evaporation slug, diam. × L 6.3 mm × 6.3 mm, ≥99.99% trace metals basis
Ti
369489
Titanium, foil, thickness 2.0 mm, 99.7% trace metals basis
Ti
348805
Titanium, foil, thickness 0.5 mm, 99.99% trace metals basis
Ti
267481
Titanium, foil, thickness 0.25 mm, 99.99% trace metals basis
Ti
267503
Titanium, foil, thickness 0.25 mm, 99.7% trace metals basis
Ti
460397
Titanium, foil, thickness 0.127 mm, ≥99.99% trace metals basis
Ti
348791
Titanium, foil, thickness 0.127 mm, 99.7% trace metals basis
Ti
348813
Titanium, foil, thickness 0.1 mm, 99.99% trace metals basis
Ti
348821
Titanium, foil, thickness 0.05 mm, 99.99% trace metals basis
Ti
348848
Titanium, foil, thickness 0.025 mm, 99.98% trace metals basis
Ti
268496
Titanium, powder, −100 mesh, 99.7% trace metals basis
Ti
366994
Titanium, powder, <45 μm avg. part. size, 99.98% trace metals basis
Ti
513415
Titanium, nanoparticles, dispersion, <100 nm particle size, in mineral oil, 98.5% trace metals basis
Ti
347132
Titanium, rod, diam. 6.35 mm, 99.99% trace metals basis
Ti
266051
Titanium, rod, diam. 6.35 mm, 99.7% trace metals basis
Ti
268526
Titanium, sponge, 3-19 mm, 99.5% trace metals basis
Ti
348856
Titanium, wire, diam. 2.0 mm, 99.99% trace metals basis
Ti
266035
Titanium, wire, diam. 1.0 mm, 99.99% trace metals basis
Ti
267902
Titanium, wire, diam. 0.81 mm, 99.7% trace metals basis
Ti
348864
Titanium, wire, diam. 0.5 mm, 99.99% trace metals basis
Ti
460400
Titanium, wire, diam. 0.25 mm, 99.7% trace metals basis
Ti
266019
Titanium, wire, diam. 0.127 mm, 99.99% trace metals basis
Ti
749044
Titanium, sputtering target, diam. × thickness 3.00 in. × 0.125 in., 99.995% trace metals basis
Ti
767506
Titanium, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.995% trace metals basis
Ti
GF57414179
Titanium, rod, 1000mm, diameter 6mm, annealed, 99.6+%
Ti
GF72693883
Titanium, rod, 100mm, diameter 1.5mm, annealed, 99.6+%
Ti