EMAIL THIS PAGE TO A FRIEND

Molecular pharmaceutics

In vivo evaluation of porous silicon and porous silicon solid lipid nanocomposites for passive targeting and imaging.


PMID 24977922

Abstract

The use of nanoparticle carriers for the sustained release of cytotoxic drugs in cancer therapy can result in fewer adverse effects and can thus be of great benefit for the patient. Recently, a novel nanocomposite, prepared by the encapsulation of THCPSi nanoparticles within solid lipids (SLN), was developed and characterized as a promising drug delivery carrier in vitro. The present study describes the in vivo evaluation of unmodified THCPSi nanoparticles and THCPSi-solid lipid nanocomposites (THCPSi-SLNCs) as potential drug delivery carriers for cancer therapy by using (18)F radiolabeling for the detection of the particle biodistribution in mice. Passive tumor targeting of (18)F-THCPSis and (18)F-THCPSi-SLNCs by the enhanced permeation and retention effect was investigated in a murine breast cancer model. Encapsulation of THCPSi nanoparticles with solid lipids improved their accumulation in tumors at a 7 week time point (tumor-to-liver ratio 0.10 ± 0.08 and 0.24 ± 0.09% for (18)F-THCPSis and (18)F-THCPSi-SLNCs, respectively).

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

M2015
1-Stearoyl-rac-glycerol, ≥99%
C21H42O4
A254
AIDA, solid
C11H11NO4
266620
Boron, crystalline, 1 cm, 99.7% trace metals basis
B
333360
Boron, crystalline, −60 mesh, 99% trace metals basis
B
332445
Boron, amorphous, powder, (submicron)
B
15580
Boron, ≥95% (boron), amorphous powder
B
GF84487674
Boron, microfoil, disks, 10mm, thinness 0.1μm, specific density 23.5μg/cm2, permanent mylar 3.5μm support, 99.6%
B
GF19976080
Boron, microfoil, disks, 25mm, thinness 0.1μm, specific density 23.5μg/cm2, permanent mylar 3.5μm support, 99.6%
B
GF81914834
Boron, monofilament, 100m, diameter 0.1mm
B
GF54382888
Boron, monofilament, 10m, diameter 0.1mm
B
GF74687080
Boron, monofilament, 10m, diameter 0.2mm
B
GF40338132
Boron, monofilament, 5m, diameter 0.2mm
B
GF97861247
Boron, monofilament, 20m, diameter 0.1mm
B
GF04144586
Boron, monofilament, 20m, diameter 0.2mm
B
GF32655315
Boron, monofilament, 50m, diameter 0.1mm
B
GF70375833
Boron, monofilament, 50m, diameter 0.2mm
B
GF98835069
Boron, monofilament, 5m, diameter 0.1mm
B
GF39354048
Boron, monofilament, 200m, diameter 0.1mm
B
746371
Sodium iodide, anhydrous, free-flowing, Redi-Dri, ACS reagent, ≥99.5%
INa
793558
Sodium iodide, anhydrous, free-flowing, Redi-Dri, ReagentPlus®, ≥99%
INa
439681
Sodium iodide, anhydrous, beads, −10 mesh, 99.999% trace metals basis
INa
409286
Sodium iodide, 99.999% trace metals basis
INa
229911
Sodium iodide, ≥99.99% trace metals basis
INa