EMAIL THIS PAGE TO A FRIEND

PloS one

Activation of Nrf2 protects against triptolide-induced hepatotoxicity.


PMID 24988078

Abstract

Triptolide, the major active component of Tripterygium wilfordii Hook f. (TWHF), has a wide range of pharmacological activities. However, the toxicities of triptolide, particularly the hepatotoxicity, limit its clinical application. The hepatotoxicity of triptolide has not been well characterized yet. The aim of this study was to investigate the role of NF-E2-related factor 2 (Nrf2) in triptolide-induced toxicity and whether activation of Nrf2 could protect against triptolide-induced hepatotoxicity. The results showed that triptolide caused oxidative stress and cell damage in HepG2 cells, and these toxic effects could be aggravated by Nrf2 knockdown or be counteracted by overexpression of Nrf2. Treatment with a typical Nrf2 agonist, sulforaphane (SFN), attenuated triptolide-induced liver dysfunction, structural damage, glutathione depletion and decrease in antioxidant enzymes in BALB/C mice. Moreover, the hepatoprotective effect of SFN on triptolide-induced liver injury was associated with the activation of Nrf2 and its downstream targets. Collectively, these results indicate that Nrf2 activation protects against triptolide-induced hepatotoxicity.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

AV54576
Anti-GCLC antibody produced in rabbit, affinity isolated antibody
HPA036359
Anti-GCLC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
HPA036360
Anti-GCLC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1405949
Anti-HMOX1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA000635
Anti-HMOX1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2101053
Anti-HMOX1 antibody produced in rabbit, affinity isolated antibody
SAB1410641
Anti-HMOX1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
SAB2501713
Anti-NFE2L2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution
SAB2701989
Anti-NFE2L2 antibody produced in rabbit
SAB2500708
Anti-NQO1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution
SAB2501434
Anti-NQO1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution
SAB1408944
Anti-NQO1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA007308
Anti-NQO1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1410299
Anti-NQO1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
S4441
DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid
C6H11NOS2
WH0002729M1
Monoclonal Anti-GCLC antibody produced in mouse, clone 3H1, purified immunoglobulin, buffered aqueous solution
WH0003162M1
Monoclonal Anti-HMOX1 antibody produced in mouse, clone 5C6, purified immunoglobulin, buffered aqueous solution
WH0004780M1
Monoclonal Anti-NFE2L2 antibody produced in mouse, clone 1F3, purified immunoglobulin, buffered aqueous solution
SAB1404123
Monoclonal Anti-NFE2L2 antibody produced in mouse, clone 2G7, purified immunoglobulin, buffered aqueous solution
SAB1409360
Monoclonal Anti-NFE2L2 antibody produced in mouse, clone 3G7, purified immunoglobulin, buffered aqueous solution
SAB1409361
Monoclonal Anti-NFE2L2 antibody produced in mouse, clone 2D5, purified immunoglobulin, buffered aqueous solution
SAB1409362
Monoclonal Anti-NFE2L2 antibody produced in mouse, clone 4C3, purified immunoglobulin, buffered aqueous solution
SAB1409363
Monoclonal Anti-NFE2L2 antibody produced in mouse, clone 1G10, purified immunoglobulin, buffered aqueous solution
WH0001728M1
Monoclonal Anti-NQO1 antibody produced in mouse, clone 1E3-A6, purified immunoglobulin, buffered aqueous solution
SAB5300232
Monoclonal Anti-NQO1 antibody produced in mouse, clone 4D12, ascites fluid
SAB5300233
Monoclonal Anti-NQO1 antibody produced in mouse, clone 1A11, ascites fluid