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Japanese journal of ophthalmology

Switching efficacy on intraocular pressure from latanoprost to bimatoprost in eyes with open angle glaucoma: implication to the changes of central corneal thickness.


PMID 25004992

Abstract

Intraocular pressure (IOP)-lowering effects of 0.03xa0% bimatoprost in eyes with open angle glaucoma (OAG) was compared with that of 0.005xa0% latanoprost. Thirty-one patients with OAG who had received three kinds of ocular hypotensive agents (latanoprost, beta-blocker, and topical carbonic anhydrase inhibitor) were included in this study. In these patients, bimatoprost was administered for 8xa0weeks after switching from latanoprost. The IOP was measured with a goldmann applanation tonometer (GAT) at the baseline, and Weeks 2, 4 and 8 after switching the treatment. The IOP at the baseline and at the end of treatment period was measured at 10:00, 12:00, and 16:00. The central corneal thickness (CCT) was measured at each visit using an ultrasonic pachymeter. At the baseline, the mean IOP was 18.8xa0±xa01.4xa0mmHg, and the CCT was 530.7xa0±xa029.5xa0μm. At Week 8 after switching treatment, bimatoprost significantly reduced the IOP by 2.0xa0±xa01.6xa0mmHg from the baseline (pxa0

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