EMAIL THIS PAGE TO A FRIEND

PloS one

Vitamin D deficiency aggravates nephrotoxicity, hypertension and dyslipidemia caused by tenofovir: role of oxidative stress and renin-angiotensin system.


PMID 25048368

Abstract

Vitamin D deficiency (VDD) is prevalent among HIV-infected individuals. Vitamin D has been associated with renal and cardiovascular diseases because of its effects on oxidative stress, lipid metabolism and renin-angiotensin-aldosterone system (RAAS). Tenofovir disoproxil fumarate (TDF), a widely used component of antiretroviral regimens for HIV treatment, can induce renal injury. The aim of this study was to investigate the effects of VDD on TDF-induced nephrotoxicity. Wistar rats were divided into four groups: control, receiving a standard diet for 60 days; VDD, receiving a vitamin D-free diet for 60 days; TDF, receiving a standard diet for 60 days with the addition of TDF (50 mg/kg food) for the last 30 days; and VDD+TDF receiving a vitamin D-free diet for 60 days with the addition of TDF for the last 30 days. TDF led to impaired renal function, hyperphosphaturia, hypophosphatemia, hypertension and increased renal vascular resistance due to downregulation of the sodium-phosphorus cotransporter and upregulation of angiotensin II and AT1 receptor. TDF also increased oxidative stress, as evidenced by higher TBARS and lower GSH levels, and induced dyslipidemia. Association of TDF and VDD aggravated renovascular effects and TDF-induced nephrotoxicity due to changes in the redox state and involvement of RAAS.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

HPA003596
Anti-AGTR1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2100073
Anti-AGTR1 antibody produced in rabbit, affinity isolated antibody
SAB3500209
Anti-AGTR1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
GW21178 Anti-ATM antibody produced in chicken, affinity isolated antibody, buffered aqueous solution
SAB3500147
Anti-ATM antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB4501968
Anti-ATM antibody produced in rabbit, affinity isolated antibody
A6218 Anti-ATM antibody, Mouse monoclonal, clone SYML6A10, purified from hybridoma cell culture
A6093 Anti-ATM antibody, Mouse monoclonal, clone SYR6D4, purified from hybridoma cell culture
N3893
Anti-Nitric Oxide Synthase, Endothelial (1185-1205) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
N2643 Anti-Nitric Oxide Synthase, Endothelial (596-609) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
SAB4300435
Anti-NOS3 (Ab-1177) antibody produced in rabbit, affinity isolated antibody
SAB4300491
Anti-NOS3 (Ab-495) antibody produced in rabbit, affinity isolated antibody
SAB1406188
Anti-NOS3 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
SAB1406792
Anti-SLC33A1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
SAB2102202
Anti-SLC33A1 antibody produced in rabbit, affinity isolated antibody
HPA042430
Anti-SLC33A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1411622
Anti-SLC33A1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
PLA0045
Goat anti-ATM Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.
SAB1402696
Monoclonal Anti-ATM antibody produced in mouse, clone 2C10, purified immunoglobulin, buffered aqueous solution
A1106
Monoclonal Anti-ATM antibody produced in mouse, ~2 mg/mL, clone MAT3-4G10/8, purified immunoglobulin, PBS solution
N9532
Monoclonal Anti-Nitric Oxide Synthase, Endothelial antibody produced in mouse, clone NOS-E1, ascites fluid
SAB5300409 Monoclonal Anti-NOS3 antibody produced in mouse, clone 6H2, ascites fluid
SAB1402291
Monoclonal Anti-NOS3 antibody produced in mouse, clone 1D12, purified immunoglobulin, buffered aqueous solution
WH0009197M7
Monoclonal Anti-SLC33A1 antibody produced in mouse, clone 3A4, purified immunoglobulin, buffered aqueous solution
PLA0086
Rabbit anti-ATM Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.