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Fertility and sterility

Blastocyst euploidy and implantation rates in a young (<35xa0years) and old (≥35xa0years) presumed fertile and infertile patient population.


PMID 25154676

Abstract

To examine the relationship between blastocyst euploidy and implantation rates in a presumed fertile patient population. Retrospective analysis. Private IVF clinic. IVF patients undergoing comprehensive chromosome screening (CCS). Embryo biopsy at the blastocyst stage with preimplantation genetic screening using CCS. Euploidy, chemical pregnancy, and implantation rates. There was no significant difference in the number of euploid blastocysts between presumed fertile (68/118, 57.6%) and infertile (75/132, 56.8%) patients<35 years old. Likewise, there was no significant difference in the number of euploid blastocysts between presumed fertile (42/86, 48.8%) and infertile (97/206, 47.1%) patients≥35 years old. When those same patients underwent a corresponding frozen embryo transfer cycle, presumed fertile patients demonstrated a significantly higher chemical pregnancy rate when compared with infertile patients, 28/33 (84.8%) and 50/81 (61.7%), respectively. Moreover, presumed fertile patients exhibited significantly higher implantation rates compared with infertile patients, 36/42 (85.7%) and 54/109 (66.7%), respectively. When subdivided by maternal age, no significant difference was seen in blastocyst euploidy rates between presumed fertile and infertile patients; however, chemical pregnancy and implantation rates were significantly higher in a presumed fertile patient population even when transferring only euploid blastocysts. This would indicate that infertility, as a disease, may encompass other aspects such as uterine or other unknown embryological factors that can influence outcomes.