EMAIL THIS PAGE TO A FRIEND

Experimental and therapeutic medicine

Immunohistochemical study of nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 in invasive breast carcinoma of no special type.


PMID 25187794

Abstract

The aim of the present study was to investigate the immunohistochemical expression of nuclear ubiquitous casein and cyclin-dependent kinases substrate 1 (NUCKS1) in invasive breast carcinoma of no special type, in association with clinicopathological characteristics, including the tumor grade, frequency of lymph node involvement and distant metastasis. In addition, associations between NUCKS1 and other tumor subtype markers, including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), Ki-67 and cytokeratin 5/6 (CK 5/6), were investigated. NUCKS1 expression was shown to be associated with the formation of distant metastases and lymph node involvement. Furthermore, an association between the presence of NUCKS1 and histological grading was observed. The results confirmed that the expression of NUCKS1 in low grade invasive breast carcinoma of no special type was significantly less common compared with cases of high grade carcinoma. With regard to the additional tumor subtype markers, NUCKS1 expression was demonstrated to be significantly associated with Ki-67 and CK 5/6; however, no association was identified with ER, PR and HER2. Therefore, NUCKS1 may be a novel prognostic marker in the histopathological evaluation of invasive breast carcinoma of no special type.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB1306027 ANTI-CHK(N-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
SAB1405616
Anti-CHKA antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
AV53583
Anti-CHKA antibody produced in rabbit, affinity isolated antibody
HPA024153
Anti-CHKA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1410167
Anti-CHKA antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
SAB1401074
Anti-CHKB antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA018797
Anti-CHKB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1408560
Anti-CHKB antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
SAB1407519
Anti-CMPK antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA053730
Anti-CMPK1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
HPA058604
Anti-CMPK1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2107657
Anti-CMPK1 antibody produced in rabbit, affinity isolated antibody
SAB1410948
Anti-CMPK1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
SAB1402586
Monoclonal Anti-CMPK antibody produced in mouse, clone 1D7, purified immunoglobulin, buffered aqueous solution