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Atherosclerosis

High-risk plaque in the superficial femoral artery of people with peripheral artery disease: prevalence and associated clinical characteristics.


PMID 25240112

Abstract

We used magnetic resonance imaging (MRI) to study the prevalence and associated clinical characteristics of high-risk plaque (defined as presence of lipid-rich necrotic core [LRNC] and intraplaque hemorrhage) in the superficial femoral arteries (SFA) among people with peripheral artery disease (PAD). The prevalence and clinical characteristics associated with high-risk plaque in the SFA are unknown. Three-hundred-three participants with PAD underwent MRI of the proximal SFA using a 1.5xa0Txa0S platform. Twelve contiguous 2.5xa0mm cross-sectional images were obtained. LRNC was present in 68 (22.4%) participants. Only one had intra-plaque hemorrhage. After adjusting for age and sex, smoking prevalence was higher among adults with LRNC than among those without LRNC (35.9% vs. 21.4%, pxa0=xa00.02). Among participants with vs. without LRNC there were no differences in mean percent lumen area (31% vs. 33%, pxa0=xa00.42), normalized mean wall area (0.71 vs. 0.70, pxa0=xa00.67) or maximum wall area (0.96 vs. 0.92, pxa0=xa00.54) in the SFA. Among participants with LRNC, cross-sectional images containing LRNC had a smaller percent lumen area (33%xa0±xa01% vs. 39%xa0±xa01%, pxa0