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Fertility and sterility

Calcium infusion for the prevention of ovarian hyperstimulation syndrome: a double-blind randomized controlled trial.


PMID 25552412

Abstract

To evaluate the role of calcium infusion as a preventive strategy of ovarian hyperstimulation syndrome (OHSS) in women at high risk in in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment cycles. Double-blinded randomized controlled trial. University hospital department of obstetrics and gynecology and private IVF center. Two hundred women at risk to develop OHSS undergoing IVF/ICSI treatment cycle. The intervention group (group 1; n = 100) received intravenous infusion of 10 mL 10% calcium gluconate in 100 mL 0.9% saline solution on the day of ovum pick-up (OPU) and days 1, 2, and 3 after, and the placebo group (group 2; n = 100) received 100 mL 0.9% saline solution on the day of OPU and days 1, 2, and 3 after. Incidence of OHSS. OHSS incidence was significantly higher in the placebo group (group 2) than in the calcium infusion group (group 1): 23 (23%) vs. 7 (7%); moderate OHSS was significantly higher in group 2 than in group 1: 8 (8%) vs. 1 (1%); and severe OHSS was significantly higher in group 2 than in group 1: 4 (4%) vs. 0. Intravenous calcium infusion effectively reduced the incidence of OHSS development without reduction in the pregnancy rate. NCT01427335.