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Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock.


PMID 25578228

Abstract

We recently derived and validated a multi-biomarker-based model (ASSIST) to stratify patients with sepsis based on initial mortality risk. The objective of this study was to compare the performance of ASSIST to interleukin-6 (IL6) and procalcitonin (PCT). The area-under-the-receiver operating characteristic curve for predicting 28-d mortality using ASSIST was compared with that of IL6 (n = 452) and PCT (n = 235). The area under the curve for ASSIST was greater than that of IL6 and PCT. ASSIST estimated the probability of mortality more reliably than IL6 and PCT in this cohort of patients with sepsis.