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Developmental cell

Regulating the timing of CENP-A nucleosome assembly by phosphorylation.


PMID 25584791

Abstract

In this issue of Developmental Cell, Yu et al. (2015) demonstrate that CENP-A phosphorylation by CDK1 inhibits its association with the chaperone protein HJURP and that the removal of this modification at mitotic exit is a key regulatory event that controls the timing of new CENP-A nucleosome formation at centromeres.