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Journal of pharmaceutical and biomedical analysis

Simultaneous determination of insulin and its analogues in pharmaceutical formulations by micellar electrokinetic chromatography.


PMID 25599910

Abstract

A simple and efficient MEKC method was developed to simultaneously determine human insulin, its five analogues, the main degradation products and the excipients usually present in injection formulations. A very fast method with a total analysis time of 3 min was then successfully validated for the analysis of human insulin and the quality control of commercial formulations was carried out.

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