EMAIL THIS PAGE TO A FRIEND

Chemical & pharmaceutical bulletin

Synthesis of new nebularine analogues and their inhibitory activity against adenosine deaminase.


PMID 25748785

Abstract

A number of new 2,6-disubstituted-1-deazanebularine analogues as well as two structurally related pyrazole-fused tricyclic nucleosides were prepared. Their synthesis was carried out by the conversion of 6-amino-2-picoline to a suitable 1-deazapurine, followed by a Vorbrüggen type glycosylation and subsequent elaboration of the condensed pyrazole ring. The synthesized nebularine analogues proved to be weak adenosine deaminase inhibitors.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

87920
Tetramethylsilane, analytical standard, for NMR spectroscopy, ACS reagent
C4H12Si