EMAIL THIS PAGE TO A FRIEND

The Analyst

Magnetic high throughput screening system for the development of nano-sized molecularly imprinted polymers for controlled delivery of curcumin.


PMID 25751126

Abstract

Curcumin is a versatile anti-inflammatory and anti-cancer agent known for its low bioavailability, which could be improved by developing materials capable of binding and releasing drug in a controlled fashion. The present study describes the preparation of magnetic nano-sized Molecularly Imprinted Polymers (nanoMIPs) for the controlled delivery of curcumin and their high throughput characterisation using microtitre plates modified with magnetic inserts. NanoMIPs were synthesised using functional monomers chosen with the aid of molecular modelling. The rate of release of curcumin from five polymers was studied under aqueous conditions and was found to correlate well with the binding energies obtained computationally. The presence of specific monomers was shown to be significant in ensuring effective binding of curcumin and to the rate of release obtained. Characterisation of the polymer particles was carried out using dynamic light scattering (DLS) technique and scanning electron microscopy (SEM) in order to establish the relationship between irradiation time and particle size. The protocols optimised during this study could be used as a blueprint for the development of nanoMIPs capable of the controlled release of potentially any compound of interest.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

T7313
1-[2-(Trifluoromethyl)phenyl]imidazole
C10H7F3N2
13270
Benzyl chloride, puriss., ≥99.5% (GC)
C7H7Cl
13280
Benzyl chloride, purum, ≥99.0% (GC)
C7H7Cl
185558
Benzyl chloride, ReagentPlus®, 99%, contains ≤1% propylene oxide as stabilizer
C7H7Cl
D0806
Diethylamine, BioXtra
C4H11N
31730
Diethylamine, puriss. p.a., ≥99.5% (GC)
C4H11N
386456
Diethylamine, purified by redistillation, 99.5%
C4H11N
471216
Diethylamine, ≥99.5%
C4H11N
D2950000
Disulfiram, European Pharmacopoeia (EP) Reference Standard
C10H20N2S4
I29204
Itaconic acid, ≥99%
C5H6O4
93598
Itaconic acid, analytical standard
C5H6O4
688886
Methyl acetoacetate, Lonza quality, ≥99% (GC)
C5H8O3
14610
Methyl acetoacetate, analytical standard
C5H8O3
537365
Methyl acetoacetate, ReagentPlus®, 99%
C5H8O3
228680
Sodium diethyldithiocarbamate trihydrate, ACS reagent
C5H10NNaS2 · 3H2O
71480
Sodium diethyldithiocarbamate trihydrate, ACS reagent, for the determination and separation of heavy metals, ≥99.0%
C5H10NNaS2 · 3H2O
71481
Sodium diethyldithiocarbamate trihydrate, ≥97.0% (NT)
C5H10NNaS2 · 3H2O
D3506
Sodium diethyldithiocarbamate trihydrate
C5H10NNaS2 · 3H2O
34399
Sodium diethyldithiocarbamate trihydrate, PESTANAL®, analytical standard
C5H10NNaS2 · 3H2O
86720
Tetraethylthiuram disulfide, ≥97.0% (S)
C10H20N2S4