EMAIL THIS PAGE TO A FRIEND

Genes and immunity

Functional variations in MBL2 gene are associated with cutaneous leishmaniasis in the Amazonas state of Brazil.


PMID 25764115

Abstract

Functional variations in the mannose-binding lectin (MBL2) gene causing low levels of serum MBL are associated with susceptibility to numerous infectious diseases. We investigated whether there is genetic association of MBL2 variant alleles with cutaneous leishmaniasis (CL) caused by Leishmania guyanensis. We used PCR-restriction fragment length polymorphism to genotype six MBL2 variants, three in the promoter region and three in the exon 1. An association was noted between the single nucleotide polymorphism -221X/Y of the MBL2 gene and CL (P=2.9 × 10(-6); odds ratio (OR)=1.9 (1.4-2.5) consistent with the hypothesis that the -221X allele confers high risk to development of CL among L. guyanensis-infected individuals. Furthermore, L. guyanensis-infected individuals bearing the codon 57 allele C had a higher risk of developing CL (P=5 × 10(-5); OR=1.9 (1.4-2.6)). The low MBL expressor haplotype LXPB was also associated to CL (P=6 × 10(-4)). This study raises the possibility that functional polymorphisms in MBL2 gene play a role in clinical outcome of Leishmania infection.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

14509
Tin, ≥99%, powder
Sn
265756
Tin, foil, thickness 0.5 mm, 99.998% trace metals basis
Sn
356948
Tin, foil, thickness 0.127 mm, 99.9%
Sn
357316
Tin, foil, thickness 0.1 mm, 99.999%
Sn
265721
Tin, foil, thickness 0.025 mm, 99.999%
Sn
243434
Tin, granular, 0.425-2.0 mm particle size, ≥99.5%, ACS reagent
Sn
576883
Tin, nanopowder, <150 nm particle size (SEM), ≥99% trace metals basis
Sn
265640
Tin, powder, <150 μm, 99.5% trace metals basis
Sn
265632
Tin, powder, <45 μm particle size, 99.8% trace metals basis
Sn
520373
Tin, powder, 10 μm, 99% trace metals basis
Sn
204692
Tin, shot, 99.999% trace metals basis
Sn
217697
Tin, 99.8%, shot, 3 mm
Sn
356956
Tin, wire, diam. 0.5 mm, 99.999% trace metals basis
Sn
265691
Tin, wire, diam. 0.25 mm, 99.99%
Sn
755702
Tin, powder, -100 mesh, 99.99% trace metals basis
Sn
GF26583194
Tin, foil, 150x150mm, thickness 0.125mm, as rolled, 98.8%
Sn
GF66339254
Tin, foil, 150x150mm, thickness 0.125mm, as rolled, 99.99+%
Sn
GF54760259
Tin, foil, 150x150mm, thickness 0.15mm, as rolled, 98.8%
Sn
GF67327375
Tin, foil, 150x150mm, thickness 0.1mm, as rolled, 98.8%
Sn
GF27720019
Tin, foil, 150x150mm, thickness 0.1mm, as rolled, 99.95%
Sn
GF16685219
Tin, foil, 150x150mm, thickness 0.20mm, as rolled, 98.8%
Sn
GF45567434
Tin, foil, 150x150mm, thickness 0.25mm, as rolled, 99.99+%
Sn
GF28603212
Tin, foil, 150x150mm, thickness 0.5mm, as rolled, 98.8%
Sn
GF28221274
Tin, foil, 150x150mm, thickness 0.5mm, as rolled, 99.99+%
Sn
GF77851323
Tin, foil, 150x150mm, thickness 1.0mm, as rolled, 98.8%
Sn
GF16505636
Tin, foil, 150x150mm, thickness 1.0mm, as rolled, 99.999%
Sn
GF50720925
Tin, foil, 150x150mm, thickness 2.0mm, as rolled, 98.8%
Sn
GF00846413
Tin, foil, 150x150mm, thickness 2.0mm, as rolled, 99.99+%
Sn
GF99151881
Tin, foil, 25x25mm, thickness 0.125mm, as rolled, 98.8%
Sn
GF83193925
Tin, foil, 25x25mm, thickness 0.125mm, as rolled, 99.99+%
Sn