EMAIL THIS PAGE TO A FRIEND

Parkinsonism & related disorders

Cerebrospinal fluid concentrations of N-acetylcysteine after oral administration in Parkinson's disease.


PMID 25765302

Abstract

Depletion of neuronal glutathione may contribute to the pathogenesis of Parkinson's disease (PD). N-acetylcysteine (NAC) can restore neuronal glutathione levels, but it has not been established whether NAC can cross the blood-brain barrier in humans. Twelve patients with PD were given oral NAC twice daily for 2 days. Three doses were compared: 7xa0mg/kg, 35xa0mg/kg, and 70xa0mg/kg. NAC, cysteine, and glutathione were measured in the cerebrospinal fluid (CSF) at baseline and 90xa0min after the last dose. Cognitive and motor functions were assessed pre- and post-NAC administration using the Montreal Cognitive Assessment (MoCA) and the Unified Parkinson's Disease Rating Scale part III motor subscore (UPDRS-III). Oral NAC produced a dose-dependent increase in CSF NAC concentrations (pxa0