EMAIL THIS PAGE TO A FRIEND

British journal of haematology

Antibody-mediated transfusion-related acute lung injury; from discovery to prevention.


PMID 25921271

Abstract

Transfusion-related acute lung injury (TRALI), a syndrome of respiratory distress caused by blood transfusion, is the leading cause of transfusion-related mortality. The majority of TRALI cases have been related to passive infusion of human leucocyte antigen (HLA) and human neutrophil antigen (HNA) antibodies in donor blood. In vitro, exxa0vivo and inxa0vivo animal models have provided insight in TRALI pathogenesis. The various classes of antibodies implicated in TRALI appear to have different pathophysiological mechanisms for the induction of TRALI involving endothelial cells, neutrophils, monocytes and, as very recently has been discovered, lymphocytes. The HLA and HNA-antibodies are found mainly in blood from multiparous women as they have become sensitized during pregnancy. The incidence of TRALI has decreased rapidly following the introduction of a male-only strategy for plasma donation. This review focuses on pre-clinical and clinical studies investigating the pathophysiology of antibody-mediated TRALI.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

HPA010592
Anti-CD74 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1400110
Anti-GCNT2 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution
HPA026776
Anti-GCNT2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1410519
Anti-GCNT2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
SAB1407025
Anti-ST6GALNAC2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
AV53653
Anti-ST6GALNAC2 antibody produced in rabbit, affinity isolated antibody
SAB2701389
Anti-ST6GALNAC2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
HPA048849
Anti-ST6GALNAC2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
HPA031734
Anti-TAF8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2106983
Anti-TAF8 antibody produced in rabbit, affinity isolated antibody
SAB1410223
Anti-TAF8 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
SAB1408305
Anti-TBN antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
SAB2106801
Anti-TCN2 antibody produced in rabbit, affinity isolated antibody
SAB1406586
Anti-VIPR1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA026777
Anti-VIPR1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB4503084
Anti-VIPR1, C-Terminal antibody produced in rabbit, affinity isolated antibody
A5282
DL-2-Amino-5-phosphonopentanoic acid, solid
C5H12NO5P
SAB1402715
Monoclonal Anti-CD74 antibody produced in mouse, clone 1D1, purified immunoglobulin, buffered aqueous solution
SAB1402938
Monoclonal Anti-TCN2 antibody produced in mouse, clone 2F4, purified immunoglobulin, buffered aqueous solution