EMAIL THIS PAGE TO A FRIEND

The Journal of investigative dermatology

Inhibition of EGFR Tyrosine Kinase by Erlotinib Prevents Sclerodermatous Graft-Versus-Host Disease in a Mouse Model.


PMID 25938558

Abstract

Chronic graft-versus-host disease (GVHD) follows allogeneic hematopoietic stem cell transplantation. It results from alloreactive processes induced by minor histocompatibility antigen incompatibilities leading to the activation of CD4 T cells and the development of fibrosis and inflammation of the skin and visceral organs and autoimmunity that resemble systemic sclerosis. EGFR is a ubiquitous cell receptor deeply involved in cell proliferation, differentiation, and motility. EGFR has recently been implicated in autoimmune and fibrotic diseases. Therefore, we tested whether Erlotinib, an EGFR tyrosine kinase inhibitor, can prevent sclerodermatous GVHD (Scl-GVHD). Scl-GVHD was induced in BALB/c mice by B10.D2 bone marrow and spleen cell transplantation. Transplanted mice displayed severe clinical symptoms including alopecia, fibrosis of the skin and visceral organs, vasculitis, and diarrhea. The symptoms were reversed in mice treated with Erlotinib. These beneficial effects were mediated by the decreased production of activated/memory CD4(+) T cells and the reduction in T-cell infiltration of the skin and visceral organs along with a decrease in IFN-γ and IL-13 production and autoimmune B-cell activation. The improvement provided by Erlotinib in the mouse model of Scl-GVHD supplies a rationale for the evaluation of Erlotinib in the management of patients affected by chronic GVHD.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB4504579
Anti-phospho-EGFR (pSer1026) antibody produced in rabbit, affinity isolated antibody
SAB4300062
Anti-phospho-EGFR (pSer1070) antibody produced in rabbit, affinity isolated antibody
SAB4504382
Anti-phospho-EGFR (pSer1070) antibody produced in rabbit, affinity isolated antibody
SAB4504580
Anti-phospho-EGFR (pSer1071) antibody produced in rabbit, affinity isolated antibody
SAB4504578
Anti-phospho-EGFR (pSer695) antibody produced in rabbit, affinity isolated antibody
SAB4300151
Anti-phospho-EGFR (pThr678) antibody produced in rabbit, affinity isolated antibody
SAB4503759
Anti-phospho-EGFR (pThr678) antibody produced in rabbit, affinity isolated antibody
SAB4300152
Anti-phospho-EGFR (pThr693) antibody produced in rabbit, affinity isolated antibody
SAB4503760
Anti-phospho-EGFR (pThr693) antibody produced in rabbit, affinity isolated antibody
SAB4503909
Anti-phospho-EGFR (pTyr1016) antibody produced in rabbit, affinity isolated antibody
SAB4504170
Anti-phospho-EGFR (pTyr1069) antibody produced in rabbit, affinity isolated antibody
SAB4300063
Anti-phospho-EGFR (pTyr1092) antibody produced in rabbit, affinity isolated antibody
SAB4504383
Anti-phospho-EGFR (pTyr1092) antibody produced in rabbit, affinity isolated antibody
SAB4300209
Anti-phospho-EGFR (pTyr1110) antibody produced in rabbit, affinity isolated antibody
SAB4504384
Anti-phospho-EGFR (pTyr1110) antibody produced in rabbit, affinity isolated antibody
SAB4300177
Anti-phospho-EGFR (pTyr1172) antibody produced in rabbit, affinity isolated antibody
SAB4504385
Anti-phospho-EGFR (pTyr1172) antibody produced in rabbit, affinity isolated antibody
SAB4300285
Anti-phospho-EGFR (pTyr1197) antibody produced in goat, affinity isolated antibody
SAB4300183
Anti-phospho-EGFR (pTyr1197) antibody produced in rabbit, affinity isolated antibody
SAB4504386
Anti-phospho-EGFR (pTyr1197) antibody produced in rabbit, affinity isolated antibody
SAB4300184
Anti-phospho-EGFR (pTyr869) antibody produced in rabbit, affinity isolated antibody
SAB4504387
Anti-phospho-EGFR (pTyr869) antibody produced in rabbit, affinity isolated antibody
E6154 Anti-phospho-Epidermal Growth Factor Receptor (pTyr1068) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution
E1530 Anti-phospho-Epidermal Growth Factor Receptor (pTyr1086) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution
E6279 Anti-phospho-Epidermal Growth Factor Receptor (pTyr1173) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution
E6029 Anti-phospho-Epidermal Growth Factor Receptor (pTyr845) antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
E0907 Anti-phospho-Epidermal Growth Factor Receptor (pTyr845) antibody produced in rabbit, affinity isolated antibody, lyophilized powder
E1780 Anti-phospho-Epidermal Growth Factor Receptor (pTyr992) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution
HPA019039
Anti-TOP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
RAB0001
Human IgG ELISA Kit, for serum, plasma