EMAIL THIS PAGE TO A FRIEND

Biochemical and biophysical research communications

Motilin stimulates pepsinogen secretion in Suncus murinus.


PMID 25957475

Abstract

Motilin and ghrelin are gastrointestinal hormones that stimulate the migrating motor complex (MMC) of gastrointestinal motility during the fasting state. In this study, we examined the effect of motilin and ghrelin on pepsinogen secretion in anesthetized suncus (house musk shrew, Suncus murinus), a ghrelin- and motilin-producing mammal. By using a gastric lumen-perfusion system, we found that the intravenous administration of carbachol and motilin stimulated pepsinogen secretion, the latter in a dose-dependent manner, whereas ghrelin had no effect. We then investigated the pathways of motilin-induced pepsinogen secretion using acetylcholine receptor antagonists. Treatment with atropine, a muscarinic acetylcholine receptor antagonist, completely inhibited both carbachol and motilin-induced pepsinogen secretion. Motilin-induced pepsinogen secretion was observed in the vagotomized suncus. This is the first report demonstrating that motilin stimulates pepsinogen secretion, and suggest that this effect occurs through a cholinergic pathway in suncus.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

H7250
Histamine dihydrochloride, ≥99% (TLC), powder
C5H9N3 · 2HCl
53300
Histamine dihydrochloride, ≥99.0% (AT)
C5H9N3 · 2HCl