EMAIL THIS PAGE TO A FRIEND

Genome biology and evolution

Analysis of Five Gene Sets in Chimpanzees Suggests Decoupling between the Action of Selection on Protein-Coding and on Noncoding Elements.


PMID 25977458

Abstract

We set out to investigate potential differences and similarities between the selective forces acting upon the coding and noncoding regions of five different sets of genes defined according to functional and evolutionary criteria: 1) two reference gene sets presenting accelerated and slow rates of protein evolution (the Complement and Actin pathways); 2) a set of genes with evidence of accelerated evolution in at least one of their introns; and 3) two gene sets related to neurological function (Parkinson's and Alzheimer's diseases). To that effect, we combine human-chimpanzee divergence patterns with polymorphism data obtained from target resequencing 20 central chimpanzees, our closest relatives with largest long-term effective population size. By using the distribution of fitness effect-alpha extension of the McDonald-Kreitman test, we reproduce inferences of rates of evolution previously based only on divergence data on both coding and intronic sequences and also obtain inferences for other classes of genomic elements (untranslated regions, promoters, and conserved noncoding sequences). Our results suggest that 1) the distribution of fitness effect-alpha method successfully helps distinguishing different scenarios of accelerated divergence (adaptation or relaxed selective constraints) and 2) the adaptive history of coding and noncoding sequences within the gene sets analyzed is decoupled.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

14509
Tin, ≥99%, powder
Sn
265756
Tin, foil, thickness 0.5 mm, 99.998% trace metals basis
Sn
356948
Tin, foil, thickness 0.127 mm, 99.9%
Sn
357316
Tin, foil, thickness 0.1 mm, 99.999%
Sn
265721
Tin, foil, thickness 0.025 mm, 99.999%
Sn
243434
Tin, granular, 0.425-2.0 mm particle size, ≥99.5%, ACS reagent
Sn
576883
Tin, nanopowder, <150 nm particle size (SEM), ≥99% trace metals basis
Sn
265640
Tin, powder, <150 μm, 99.5% trace metals basis
Sn
265632
Tin, powder, <45 μm particle size, 99.8% trace metals basis
Sn
520373
Tin, powder, 10 μm, 99% trace metals basis
Sn
204692
Tin, shot, 99.999% trace metals basis
Sn
217697
Tin, 99.8%, shot, 3 mm
Sn
356956
Tin, wire, diam. 0.5 mm, 99.999% trace metals basis
Sn
265691
Tin, wire, diam. 0.25 mm, 99.99%
Sn
755702
Tin, powder, -100 mesh, 99.99% trace metals basis
Sn
GF26583194
Tin, foil, 150x150mm, thickness 0.125mm, as rolled, 98.8%
Sn
GF66339254
Tin, foil, 150x150mm, thickness 0.125mm, as rolled, 99.99+%
Sn
GF54760259
Tin, foil, 150x150mm, thickness 0.15mm, as rolled, 98.8%
Sn
GF67327375
Tin, foil, 150x150mm, thickness 0.1mm, as rolled, 98.8%
Sn
GF27720019
Tin, foil, 150x150mm, thickness 0.1mm, as rolled, 99.95%
Sn
GF16685219
Tin, foil, 150x150mm, thickness 0.20mm, as rolled, 98.8%
Sn
GF45567434
Tin, foil, 150x150mm, thickness 0.25mm, as rolled, 99.99+%
Sn
GF28603212
Tin, foil, 150x150mm, thickness 0.5mm, as rolled, 98.8%
Sn
GF28221274
Tin, foil, 150x150mm, thickness 0.5mm, as rolled, 99.99+%
Sn
GF77851323
Tin, foil, 150x150mm, thickness 1.0mm, as rolled, 98.8%
Sn
GF16505636
Tin, foil, 150x150mm, thickness 1.0mm, as rolled, 99.999%
Sn
GF50720925
Tin, foil, 150x150mm, thickness 2.0mm, as rolled, 98.8%
Sn
GF00846413
Tin, foil, 150x150mm, thickness 2.0mm, as rolled, 99.99+%
Sn
GF99151881
Tin, foil, 25x25mm, thickness 0.125mm, as rolled, 98.8%
Sn
GF83193925
Tin, foil, 25x25mm, thickness 0.125mm, as rolled, 99.99+%
Sn