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Molecular medicine reports

Continuous expression of CD83 on activated human CD4⁺ T cells is correlated with their differentiation into induced regulatory T cells.


PMID 25997495

Abstract

CD83 is a widely recognized surface marker for mature dendritic cells, which are essential for priming naïve CD4+ Txa0cells into effector cells. However, CD83 is also expressed on activated CD4+ Txa0cells, which remains an enigma in T‑cell mediated immunity. Therefore, the identification of the biological features and regulation of the expression of CD83 on activated CD4+ Txa0cells is important in understanding the function of CD83 in the adaptive immune response. The present study revealed a time‑dependent manner of the expression of CD83 on anti‑CD3/CD28‑stimulated human CD4+ Txa0cells, which is characterized by the maximum expression at dayxa02 and a significant decrease at dayxa03. The reduced expression is not a result of a reduced rate of cell proliferation. The activation of interleukin‑2 and secretion of interferon‑γ accumulated progressively from dayxa01 to 3. Of note, sustained expression of CD83 was observed when CD4+ Txa0cells were induced by transforming growth factor-β to differentiate into CD4+CD25+ forkhead box P3+ regulatory T (iTreg) cells. Confocal immunofluorescence microscopy analysis demonstrated that CD83 was highly co‑localized with CD25 on activated CD4+ Txa0cells. In conclusion, the findings of the present study suggested that the continuous expression of CD83 on activated human CD4+ T cells is correlated with their differentiation into iTreg cells.