EMAIL THIS PAGE TO A FRIEND

Journal of neuroimmunology

Reduction of inflammation and preservation of neurological function by anti-CD52 therapy in murine experimental autoimmune encephalomyelitis.


PMID 26198912

Abstract

Alemtuzumab, a monoclonal antibody directed against human CD52, is used in the treatment of MS. To characterize the impact of anti-CD52 administration, a monoclonal antibody to mouse CD52 (anti-muCD52) was generated and evaluated in EAE mouse models of MS. A single course of anti-muCD52 provided a therapeutic benefit accompanied by a reduction in the frequency of autoreactive T lymphocytes and production of pro-inflammatory cytokines. Examination of the CNS revealed a decrease in infiltrating lymphocytes, demyelination and axonal loss. Electrophysiological assessment showed preservation of axonal conductance in the spinal cord. These findings suggest that anti-CD52 therapy may help preserve CNS integrity.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB1405987
Anti-CFI antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA001143
Anti-CFI antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
HPA024061
Anti-CFI antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1410687
Anti-CFI antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
SAB1405869
Anti-GIF antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA039908
Anti-GIF antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
HPA040774
Anti-GIF antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1410525
Anti-GIF antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
M3821 Anti-Myelin Basic Protein (MBP) antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
SAB3700627 Anti-Rat IgG (H+L), F(ab′)2 fragment antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB3700657 Anti-Rat IgG (H+L), F(ab) fragment antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
GHS1128
Hematoxylin Solution, Gill No. 1
SAB1402207
Monoclonal Anti-GIF, (C-terminal) antibody produced in mouse, clone 1D9, purified immunoglobulin, buffered aqueous solution
WH0003426M1
Monoclonal Anti-IF antibody produced in mouse, clone 1B3, purified immunoglobulin, buffered aqueous solution