EMAIL THIS PAGE TO A FRIEND

Reproductive biology and endocrinology : RB&E

Placental lipase expression in pregnancies complicated by preeclampsia: a case-control study.


PMID 26336959

Abstract

Preeclampsia (PE) is associated with maternal and neonatal morbidity and mortality. In PE, the physiological hyperlipidaemia of pregnancy is exaggerated. The purpose of this study was to examine the expression of adipose triglyceride lipase (ATGL), hormone sensitive lipase (HSL), lipoprotein lipase (LPL) and endothelial lipase (EL) in pregnancies complicated by PE. Placentae were collected from 16 women with PE and 20 women with uncomplicated pregnancies matched for maternal prepregnancy BMI and gestational age of delivery. Gene and protein expression of the placental lipases were measured by Q-PCR and Western blot. DNA methylation of the promoter of LPL was assessed by bisulfite sequencing. Lipase localisation and activity were analysed. Gene expression of all lipases was significantly reduced, as was HSL protein level in women with PE. All lipases were localised to trophoblasts and endothelial cells in PE and control placentae. There was no difference in methylation of the LPL promoter between PE and control placentae. Lipase activity was not altered in placentae from women with PE. These results suggest that the decreased placental lipase gene but not protein expression or lipase activity, which is associated with late-onset PE is not a major contributor to the abnormal lipids seen in PE.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

D6875
21-Hydroxyprogesterone, ≥97% (HPLC)
C21H30O3
SAB2500353
Anti-Endothelial Lipase antibody produced in goat, affinity isolated antibody, buffered aqueous solution
SAB4501762
Anti-HSL antibody produced in rabbit, affinity isolated antibody
SAB4501763
Anti-HSL antibody produced in rabbit, affinity isolated antibody
SAB2101327
Anti-LCP1 (ab1) antibody produced in rabbit, affinity isolated antibody
SAB2101328
Anti-LCP1 (ab2) antibody produced in rabbit, affinity isolated antibody
SAB2701641
Anti-lcp1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB2701743
Anti-lcp1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
HPA019493
Anti-LCP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
PRS3965
Anti-Lipe antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB2900275
Anti-LIPE antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB1406817
Anti-LIPG antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA016966
Anti-LIPG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2101350
Anti-LIPG antibody produced in rabbit, affinity isolated antibody
SAB1406091
Anti-LPL antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
SAB1401231
Anti-LPL antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
SAB2700761
Anti-LPL antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB2701143
Anti-LPL antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB2701144
Anti-LPL antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB1407769
Anti-PNPLA2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
SAB1411126
Anti-PNPLA2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
WH0009388M2
Monoclonal Anti-LIPG antibody produced in mouse, clone 1E11, purified immunoglobulin, buffered aqueous solution
SAB1404712
Monoclonal Anti-LIPG, (C-terminal) antibody produced in mouse, clone 4A9, purified immunoglobulin, buffered aqueous solution
SAB5300056
Monoclonal Anti-LPL antibody produced in mouse, clone 2C5, ascites fluid
WH0057104M1
Monoclonal Anti-PNPLA2 antibody produced in mouse, clone 2H1, purified immunoglobulin, buffered aqueous solution