EMAIL THIS PAGE TO A FRIEND

BMC genomics

Genome-wide target analysis of NEUROD2 provides new insights into regulation of cortical projection neuron migration and differentiation.


PMID 26341353

Abstract

Cellular differentiation programs are controlled, to a large extent, by the combinatorial functioning of specific transcription factors. Cortical projection neurons constitute the major excitatory neuron population within the cortex and mediate long distance communication between the cortex and other brain regions. Our understanding of effector transcription factors and their downstream transcriptional programs that direct the differentiation process of cortical projection neurons is far from complete. In this study, we carried out a ChIP-Seq (chromatin-immunoprecipitation and sequencing) analysis of NEUROD2, an effector transcription factor expressed in lineages of cortical projection neurons during the peak of cortical excitatory neurogenesis. Our results suggest that during cortical development NEUROD2 targets key genes that are required for Reelin signaling, a major pathway that regulates the migration of neurons from germinal zones to their final layers of residence within the cortex. We also find that NEUROD2 binds to a large set of genes with functions in layer-specific differentiation and in axonal pathfinding of cortical projection neurons. Our analysis of in vivo NEUROD2 target genes offers mechanistic insight into signaling pathways that regulate neuronal migration and axon guidance and identifies genes that are likely to be required for proper cortical development.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB1408196
Anti-ATPIF1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
SAB2100188
Anti-ATPIF1 antibody produced in rabbit, affinity isolated antibody
HPA027999
Anti-ATPIF1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
HPA000426
Anti-IKBKG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
AV30005
Anti-IKBKG antibody produced in rabbit, IgG fraction of antiserum
SAB2103956
Anti-IKBKG, (N-terminal) antibody produced in rabbit, affinity isolated antibody
SAB4503404
Anti-IKK-γ antibody produced in rabbit, affinity isolated antibody
GW21172 Anti-NEMO antibody produced in chicken, affinity isolated antibody, buffered aqueous solution
AV38741
Anti-NEUROD2 (AB1) antibody produced in rabbit, affinity isolated antibody
AV32037
Anti-NEUROD2 (AB2) antibody produced in rabbit, IgG fraction of antiserum
SAB1410836
Anti-NEUROD2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
N6286 Anti-Neurogenin 2 antibody produced in rabbit, affinity isolated antibody, ammonium sulfate suspension
P7622 Anti-Prostacyclin Receptor antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB4502486
Anti-Prostacyclin Receptor antibody produced in rabbit, affinity isolated antibody
SAB2500916
Anti-SDHB antibody produced in goat, affinity isolated antibody, buffered aqueous solution
HPA002867
Anti-SDHB antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2102103
Anti-SDHB antibody produced in rabbit, affinity isolated antibody
HPA002868
Anti-SDHB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2106796
Anti-SDHB antibody produced in rabbit, affinity isolated antibody
SAB1411242
Anti-SDHB antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
WH0093974M1
Monoclonal Anti-ATPIF1 antibody produced in mouse, clone 3E2, purified immunoglobulin, buffered aqueous solution
WH0008517M1
Monoclonal Anti-IKBKG antibody produced in mouse, clone 4G9, purified immunoglobulin, buffered aqueous solution
SAB1404591
Monoclonal Anti-IKBKG, (N-terminal) antibody produced in mouse, clone 1D4, purified immunoglobulin, buffered aqueous solution
SAB1402287
Monoclonal Anti-NEUROD2 antibody produced in mouse, clone 3E7, purified immunoglobulin, buffered aqueous solution
WH0005739M1
Monoclonal Anti-PTGIR antibody produced in mouse, clone 4B10, purified immunoglobulin, buffered aqueous solution
SAB1404273
Monoclonal Anti-PTGIR, (C-terminal) antibody produced in mouse, clone 2A7, purified immunoglobulin, buffered aqueous solution
AMAB90708
Monoclonal Anti-SDHB antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0349, purified immunoglobulin, buffered aqueous glycerol solution
AMAB90706
Monoclonal Anti-SDHB antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0347, purified immunoglobulin, buffered aqueous glycerol solution