EMAIL THIS PAGE TO A FRIEND

Carbohydrate polymers

Effect of the molecular architecture on the thermosensitive properties of chitosan-g-poly(N-vinylcaprolactam).


PMID 26428104

Abstract

A series of thermoresponsive copolymers based on chitosan-g-poly(N-vinylcaprolactam) were synthesized by amidation reaction using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride as coupling reagent. The effect of molecular architecture on the thermoresponsive properties of the graft copolymers solutions was studied by varying the chain length of the grafted poly(N-vinylcaprolactam), PVCL, (in the range from 4 to 26 kDa) and the spacing between grafted chains onto the chitosan backbone. The most interesting characteristic of these copolymers is their solubility in water at temperatures below their lower critical solution temperature (LCST). These solutions presented a LCST between 36 and 44 °C, which decreases with the spacing and length of grafted PVCL chains onto the chitosan backbone, in contrast with the limited decrease of the LCST of PVCL above a critical M¯n value around 18 kDa. This behavior offers tangible possibilities for the preparation and application of sensitive bioactive formulations and "smart" drug delivery systems.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

I9516
2-Propanol, BioReagent, for molecular biology, ≥99.5%
C3H8O
278475
2-Propanol, anhydrous, 99.5%
C3H8O
675431
2-Propanol, HPLC Plus, for HPLC, GC, and residue analysis, 99.9%, poly coated bottles
C3H8O
437522
2-Propanol, ACS reagent, ≥99.5%
C3H8O
59304
2-Propanol, BioUltra, for molecular biology, ≥99.5% (GC)
C3H8O
40301
2-Propanol, semiconductor grade VLSI PURANAL (Honeywell 17604)
C3H8O
40219
2-Propanol, semiconductor grade PURANAL (Honeywell 17829)
C3H8O
40279
2-Propanol, semiconductor grade MOS PURANAL (Honeywell 17930)
C3H8O
270490
2-Propanol, 99.5%, HPLC grade
C3H8O
15-2360
2-Propanol, for HPLC
C3H8O
733458
2-Propanol, electronic grade, 99.999% trace metals basis
C3H8O
74104
4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, ≥96.0% (calc. on dry substance, AT)
C10H17ClN4O3
439126
Acetone, for HPLC, ≥99.9%
C3H6O
00561
Acetone, for luminescence, ≥99.5% (GC)
C3H6O
40289
Acetone, semiconductor grade VLSI PURANAL (Honeywell 17617)
C3H6O
W332607
Acetone, ≥99%, meets FCC analytical specifications
C3H6O
W332615
Acetone, natural, ≥97%
C3H6O
01-0520
Acetone, for HPLC
C3H6O
01-0494
Acetone, for residue analysis, suitable for 5000 per JIS
C3H6O
01-0475
Acetone, suitable for determination of dioxins
C3H6O
48358
Acetone solution, certified reference material, 2000 μg/mL in methanol: water (9:1)
C3H6O
686530
Acetone solution, contains 20.0 % (v/v) acetonitrile, for HPLC
C3H6O
W292907
Isopropyl alcohol, ≥99.7%, FCC, FG
C3H8O
D4551
N,N-Dimethylformamide, for molecular biology, ≥99%
C3H7NO
227056
N,N-Dimethylformamide, anhydrous, 99.8%
C3H7NO
648531
N,N-Dimethylformamide, for HPLC, ≥99.9%
C3H7NO
437573
N,N-Dimethylformamide, ACS reagent, ≥99.8%
C3H7NO
T3758
Thioglycolic acid, ≥98%
C2H4O2S
528056
Thioglycolic acid, ≥99%
C2H4O2S
T6750
Thioglycolic acid solution, ~70 % (w/w) in H2O
C2H4O2S