EMAIL THIS PAGE TO A FRIEND

Cancer letters

TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma.


PMID 26433159

Abstract

Hepatocellular carcinoma (HCC) is a common cancer worldwide and the third leading cause of cancer death. Immunotherapy is considered a promising treatment with the aim to boost or arouse HCC-specific immune responses. TLR7 and TLR8 agonists are effective immunomodulators and have been applied topically for the treatment of certain skin tumors and viral infections. Here, we explored the role of TLR7 and TLR8 agonists on the activation of dendritic cells (DCs) and natural killer (NK) cells. We demonstrated that these agonists could directly activate NK cells, promoting the maturation of immature DCs. Meanwhile, DCs also assisted in the function of NK cells, resulting in enhanced anti-tumor immune responses to HCC. Importantly, the combination therapy with NK cells stimulated with DCs and TLR7/8 agonist Gardiquimod (GDQ) significantly suppresses the growth of human HepG2 liver carcinoma xenografts. This study provides a new immunotherapeutic approach for human HCC based on DC-NK cross-talk and also suggests that TLR7 and/or TLR8 agonists, particularly GDQ, may serve as potent innate and adaptive immune response immunomodulators in tumor therapy.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB2700447
Anti-C5 (C-terminal) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB1303159 ANTI-C5 (N-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
HPA029339
Anti-C5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SRP3211 IL-4 from mouse, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SRP4137 IL-4 human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
SRP6172
IL-4 human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
SRP3093 IL-4 human, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
I1020 Interleukin-4 from mouse, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
I3650 Interleukin-4 from rat, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)
I4269 Interleukin-4 human, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
I2661 Interleukin-4 human, IL-4, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), animal component free
WH0001213M5
Monoclonal Anti-CLTC antibody produced in mouse, clone 2E5, purified immunoglobulin, buffered aqueous solution