EMAIL THIS PAGE TO A FRIEND

The Journal of biological chemistry

Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.


PMID 26463208

Abstract

Plasmalogen biosynthesis is regulated by modulating fatty acyl-CoA reductase 1 stability in a manner dependent on cellular plasmalogen level. However, physiological significance of the regulation of plasmalogen biosynthesis remains unknown. Here we show that elevation of the cellular plasmalogen level reduces cholesterol biosynthesis without affecting the isoprenylation of proteins such as Rab and Pex19p. Analysis of intermediate metabolites in cholesterol biosynthesis suggests that the first oxidative step in cholesterol biosynthesis catalyzed by squalene monooxygenase (SQLE), an important regulator downstream HMG-CoA reductase in cholesterol synthesis, is reduced by degradation of SQLE upon elevation of cellular plasmalogen level. By contrast, the defect of plasmalogen synthesis causes elevation of SQLE expression, resulting in the reduction of 2,3-epoxysqualene required for cholesterol synthesis, hence implying a novel physiological consequence of the regulation of plasmalogen biosynthesis.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB2104823
Anti-CYP2B6 antibody produced in rabbit, affinity isolated antibody
HPA048124
Anti-CYP2B6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB4500588
Anti-Cytochrome P450 2B6 antibody produced in rabbit, affinity isolated antibody
SAB1406474
Anti-SQLE antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
AV42101
Anti-SQLE antibody produced in rabbit, affinity isolated antibody
HPA018038
Anti-SQLE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
HPA020762 Anti-SQLE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1411313
Anti-SQLE antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
L5768
Lanosterol, ≥93%, powder
C30H50O
M2147
Mevinolin from Aspergillus sp., ≥98% (HPLC)
C24H36O5
EHU000321 MISSION® esiRNA, esiRNA targeting human THBD (esiRNA1)
EHU079921 MISSION® esiRNA, esiRNA human MCL1 (esiRNA1)
EMU077471 MISSION® esiRNA, esiRNA targeting mouse Thbd (esiRNA1)
EMU064061 MISSION® esiRNA, esiRNA targeting mouse Mcl1 (esiRNA1)
S3626
Squalene, ≥98%, liquid
C30H50
442785
Squalene, analytical standard
C30H50