EMAIL THIS PAGE TO A FRIEND

Oncology letters

SMAD4 expression in breast ductal carcinoma correlates with prognosis.


PMID 26622737

Abstract

The present study examined SMAD4 expression in fine-needle aspiration cell blocks from patients with breast ductal carcinoma, in order to assess its viability as a prognostic marker. Using immunohistochemistry, the SMAD4 protein status of 86 breast ductal carcinoma fine-needle biopsies, from patients who underwent tumor resection at Beihua University Affiliated Hospital (Jilin, China) between 2002 and 2008, was characterized. The association between SMAD4 expression and clinicopathological parameters, as well as prognosis was assessed using the Mantel-Haenszel method and Cox proportional hazards regression. SMAD4 staining was observed in the cytoplasm and nucleus, and its expression was found to be decreased in ductal breast carcinoma as compared with adjacent normal breast epithelia. Patients with reduced SMAD4 expression levels tended to exhibit more poorly differentiated tumors, a higher risk of recurrence and shorter overall survival. These results demonstrated that the evaluation of SMAD4 protein status in fine-needle biopsy specimens of breast ductal carcinoma may provide additional prognostic information.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB1412048
ANTI-SMAD4 antibody produced in mouse, clone 4C5, purified immunoglobulin, buffered aqueous solution
SAB1412049
ANTI-SMAD4 antibody produced in mouse, clone 4C6, purified immunoglobulin, buffered aqueous solution
SAB1412182
ANTI-SMAD4 antibody produced in mouse, clone 3D7, purified immunoglobulin, buffered aqueous solution
SAB1412494
ANTI-SMAD4 antibody produced in mouse, clone 4A6, purified immunoglobulin, buffered aqueous solution
SAB1412495
ANTI-SMAD4 antibody produced in mouse, clone 2G4, purified immunoglobulin, buffered aqueous solution
SAB1412496
ANTI-SMAD4 antibody produced in mouse, clone 3H1, purified immunoglobulin, buffered aqueous solution
SAB1412497
ANTI-SMAD4 antibody produced in mouse, clone 2C1, purified immunoglobulin, buffered aqueous solution
SAB1412498
ANTI-SMAD4 antibody produced in mouse, clone 4D12, purified immunoglobulin, buffered aqueous solution
SAB1412512
ANTI-SMAD4 antibody produced in mouse, clone 1A5, purified immunoglobulin, buffered aqueous solution
SAB1412596
ANTI-SMAD4 antibody produced in mouse, clone 1G9, purified immunoglobulin, buffered aqueous solution
SAB1412597
ANTI-SMAD4 antibody produced in mouse, clone 2E7, purified immunoglobulin, buffered aqueous solution
HPA019154
Anti-SMAD4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB4200405
Anti-SMAD4 antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody
SAB2106277
Anti-SMAD4 antibody produced in rabbit, affinity isolated antibody
SAB1404038
Monoclonal Anti-SMAD4 antibody produced in mouse, clone 3E2, purified immunoglobulin, buffered aqueous solution
SAB5300375 Monoclonal Anti-SMAD4 antibody produced in mouse, clone 4G1C6, ascites fluid