EMAIL THIS PAGE TO A FRIEND

Scientific reports

Drug Signature-based Finding of Additional Clinical Use of LC28-0126 for Neutrophilic Bronchial Asthma.


PMID 26626943

Abstract

In recent decades, global pharmaceutical companies have suffered from an R&D innovation gap between the increased cost of a new drug's development and the decreased number of approvals. Drug repositioning offers another opportunity to fill the gap because the approved drugs have a known safety profile for human use, allowing for a reduction of the overall cost of drug development by eliminating rigorous safety assessment. In this study, we compared the transcriptional profile of LC28-0126, an investigational drug for acute myocardial infarction (MI) at clinical trial, obtained from healthy male subjects with molecular activity profiles in the Connectivity Map. We identified dyphilline, an FDA-approved drug for bronchial asthma, as a top ranked connection with LC28-0126. Subsequently, we demonstrated that LC28-0126 effectively ameliorates the pathophysiology of neutrophilic bronchial asthma in OVALPS-OVA mice accompanied with a reduction of inflammatory cell counts in the bronchoalveolar lavage fluid (BALF), inhibition of the release of proinflammatory cytokines, relief of airway hyperactivity, and improvement of histopathological changes in the lung. Taken together, we suggest that LC28-0126 could be a potential therapeutic for bronchial asthma. In addition, this study demonstrated the potential general utility of computational drug repositioning using clinical profiles of the investigational drug.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

C102
8-Cyclopentyl-1,3-dimethylxanthine, ≥98% (HPLC), powder
C12H16N4O2
AV07032
Anti-CXCL1 antibody produced in rabbit, affinity isolated antibody
SAB1410581
Anti-CXCL1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
GW21038 Anti-GRO1 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution
PRS4877
Anti-IL-17 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
PRS4887
Anti-IL-17 (ab2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
HPA042421
Anti-IL13 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2502114
Anti-IL17A antibody produced in goat, affinity isolated antibody, buffered aqueous solution
SAB2502115
Anti-IL17A antibody produced in goat, affinity isolated antibody, buffered aqueous solution
HPA052258
Anti-IL17A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
AV54329
Anti-IL4 antibody produced in rabbit, affinity isolated antibody
SAB2103750
Anti-IL4 antibody produced in rabbit, affinity isolated antibody
SAB2101153
Anti-IL5 antibody produced in rabbit, affinity isolated antibody, lyophilized powder
SAB2107055
Anti-IL5 antibody produced in rabbit, affinity isolated antibody
I7776 Anti-Interleukin-4 antibody produced in goat, affinity isolated antibody, lyophilized powder
I7526 Anti-Interleukin-4 antibody produced in goat, affinity isolated antibody, lyophilized powder
I8784 Anti-Interleukin-4 antibody produced in goat, IgG fraction of antiserum, lyophilized powder
I9898 Anti-Interleukin-5 antibody produced in goat, IgG fraction of antiserum, lyophilized powder
S5770
Citrate Concentrated Solution, BioReagent, suitable for coagulation assays, 4 % (w/v)
C6H5Na3O7
83273
Citrate Concentrated Solution, BioUltra, for molecular biology, 1 M in H2O
C6H5Na3O7
WH0000796M1
Monoclonal Anti-CALCA antibody produced in mouse, clone 4B10, purified immunoglobulin, buffered aqueous solution
WH0002919M1
Monoclonal Anti-CXCL1 antibody produced in mouse, clone 7A11, purified immunoglobulin, buffered aqueous solution
SAB1403887
Monoclonal Anti-CXCL1 antibody produced in mouse, clone 2D7, purified immunoglobulin, buffered aqueous solution
SAB3701439
Monoclonal Anti-IL-17A antibody produced in mouse, clone 4H1524.1, purified immunoglobulin
SAB3701458
Monoclonal Anti-IL-17A antibody produced in rat, clone 20B4.G10.F5, purified immunoglobulin
WH0003596M1
Monoclonal Anti-IL13 antibody produced in mouse, clone 7E4, purified immunoglobulin, buffered aqueous solution
SAB1403976
Monoclonal Anti-IL13 antibody produced in mouse, clone 3H7, purified immunoglobulin, buffered aqueous solution
SAB1402819 Monoclonal Anti-IL4, (C-terminal) antibody produced in mouse, clone 3D11, purified immunoglobulin, buffered aqueous solution
I3407 Monoclonal Anti-Interleukin-13 antibody produced in mouse, clone 32116.11, purified immunoglobulin, lyophilized powder
I4532 Monoclonal Anti-Interleukin-13 antibody produced in rat, clone 38213.11, purified immunoglobulin, lyophilized powder