EMAIL THIS PAGE TO A FRIEND

PloS one

Euterpe oleracea Mart.-Derived Polyphenols Protect Mice from Diet-Induced Obesity and Fatty Liver by Regulating Hepatic Lipogenesis and Cholesterol Excretion.


PMID 26630290

Abstract

The aim of this study was to investigate the effect of a polyphenol-rich Açaí seed extract (ASE, 300 mg/kg-1d-1) on adiposity and hepatic steatosis in mice that were fed a high-fat (HF) diet and its underlying mechanisms based on hepatic lipid metabolism and oxidative stress. Four groups were studied: C57BL/6 mice that were fed with standard diet (10% fat, Control), 10% fat + ASE (ASE), 60% fat (HF), and 60% fat + ASE (HF + ASE) for 12 weeks. We evaluated the food intake, body weight gain, serum glucose and lipid profile, hepatic cholesterol and triacyglycerol (TG), hepatic expression of pAMPK, lipogenic proteins (SREBP-1c, pACC, ACC, HMG-CoA reductase) and cholesterol excretion transporters, ABCG5 and ABCG8. We also evaluated the steatosis in liver sections and oxidative stress. ASE reduced body weight gain, food intake, glucose levels, accumulation of cholesterol and TG in the liver, which was associated with a reduction of hepatic steatosis. The increased expressions of SREBP-1c and HMG-CoA reductase and reduced expressions of pAMPK and pACC/ACC in HF group were antagonized by ASE. The ABCG5 and ABCG8 transporters expressions were increased by the extract. The antioxidant effect of ASE was demonstrated in liver of HF mice by restoration of SOD, CAT and GPx activities and reduction of the increased levels of malondialdehyde and protein carbonylation. In conclusion, ASE substantially reduced the obesity and hepatic steatosis induced by HF diet by reducing lipogenesis, increasing cholesterol excretion and improving oxidative stress in the liver, providing a nutritional resource for prevention of obesity-related adiposity and hepatic steatosis.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

85707
2,5-Dihydroxybenzoic acid, matrix substance for MALDI-MS, >99.0% (HPLC)
C7H6O4
149357
2,5-Dihydroxybenzoic acid, 98%
C7H6O4
H6132
DL-3-Hydroxy-3-methylglutaryl coenzyme A sodium salt hydrate, ≥90% (HPLC)
C27H42N7Na2O20P3S · xH2O
270989
Ethyl acetate, anhydrous, 99.8%
C4H8O2
319902
Ethyl acetate, ACS reagent, ≥99.5%
C4H8O2
437549
Ethyl acetate, ACS reagent, ≥99.5%
C4H8O2
324027
Ethyl acetate, PRA grade, ≥99.5%
C4H8O2
45767
Ethyl acetate, puriss. p.a., free of higher boiling impurities, ≥99.9% (GC)
C4H8O2
33211
Ethyl acetate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.5% (GC)
C4H8O2
27227
Ethyl acetate, puriss., meets analytical specification of Ph. Eur., BP, NF, ≥99.5% (GC)
C4H8O2
270520
Ethyl acetate, HPLC grade, 99.8%
C4H8O2
W241407
Ethyl acetate, ≥99%, FCC, FG
C4H8O2
09-0703
Ethyl acetate, for residue analysis, suitable for 5000 per JIS
C4H8O2
09-0730
Ethyl acetate, for HPLC
C4H8O2
W241415
Ethyl acetate, natural, ≥99%, FCC, FG
C4H8O2
537446
Ethyl acetate, ReagentPlus®, ≥99.8%
C4H8O2
L092004
Ethyl acetate
C4H8O2
L092003
Ethyl acetate
C4H8O2
40276
Hydrofluoric acid, semiconductor grade MOS PURANAL (Honeywell 17928), 49.5-50.5%
HF
RES0926S-A7
Sodium chloride, PharmaGrade, USP, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production.
ClNa
S7653
Sodium chloride, BioXtra, ≥99.5% (AT)
ClNa
S3014
Sodium chloride, for molecular biology, DNase, RNase, and protease, none detected, ≥98% (titration)
ClNa
S5886
Sodium chloride, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99%
ClNa
S1679
Sodium chloride, meets analytical specification of Ph. Eur., BP, USP, 99.0-100.5%
ClNa
S6150
Sodium chloride, tablet
ClNa
S6191
Sodium chloride, BioPerformance Certified, ≥99% (titration), Cell Culture Tested
ClNa
450006
Sodium chloride, anhydrous, beads, −10 mesh, 99.999% trace metals basis
ClNa
450014
Sodium chloride, anhydrous, beads, −10 mesh, 99.99% trace metals basis
ClNa
204439
Sodium chloride, 99.999% trace metals basis
ClNa
378860
Sodium chloride, random crystals, optical grade, 99.98% trace metals basis
ClNa