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Journal of animal physiology and animal nutrition

Uptake of manganese from manganese-lysine complex in the primary rat intestinal epithelial cells.


PMID 26671483

Abstract

This study was conducted to compare the differences of the uptake of Mn from Mn-lysine complex (MnLys) and MnSO4 and to determine the potential mechanisms of the uptake of Mn from MnLys. We first established the primary rat intestinal epithelial cell culture model and used it to determine the uptake of Mn from different Mn sources. The MnLys increased (pxa0xa00.06) Mn(2+) influx transporter DMT1 mRNA expression when compared to MnSO4 . The results above indicated that the increase of Mn accumulation for MnLys at least partly was due to the decrease of Mn efflux by reduced FPN1 expression. The N-ethylmaleimide, as an l-lysine transport system y(+) inhibitor, decreased (pxa0xa00.10) the uptake of Mn from MnSO4 . The cycloheximide, as an l-lysine transport system b(0,+) activator, increased (pxa0

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