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Journal of veterinary pharmacology and therapeutics

Pharmacokinetics and tissue residues of moroxydine hydrochloride in gibel carp, Carassius gibelio after oral administration.


PMID 26763124

Abstract

The pharmacokinetics and tissue residues of moroxydine hydrochloride were studied in gibel carp at water temperature of 15 and 25xa0°C. Samples (blood, skin, muscle, liver, and kidney) were collected over 10xa0days after the treatment and analyzed by high-performance liquid chromatography with anxa0ultraviolet detector. The results indicated that the influence of water temperature on the metabolism of the drug was significant. The plasma concentration-time data of moroxydine hydrochloride conformed to single-compartment open model at the two water temperatures. There were higher absorption rate (t1/2ka ) and longer elimination half-lives (t1/2ke ) at 15xa0°C (4.29 and 15.87xa0h, respectively) compared with those at 25xa0°C (3.02 and 4.22xa0h, respectively). The maximum plasma concentration (Cmax ) and the time-point of maximum plasma concentration (Tp ) were 2.98 μg/mL and 10.35xa0h at 15xa0°C and 3.12 μg/mL and 4.03xa0h at 25xa0°C, respectively. The distribution volume (Vd /F) of moroxydine hydrochloride was estimated to be 4.55xa0L/kg at 15xa0°C and 2.89xa0L/kg at 25xa0°C. The total body clearance (CLb ) of moroxydine hydrochloride was determined to be 0.25 and 0.49xa0L/(h·kg) at 15xa0°C and 25xa0°C, respectively; the areas under the concentration-time curve were 75.89 μg·h/mL at 15xa0°C and 42.33 μg·h/mL at 25xa0°C. The depletion of moroxydine hydrochloride in gibel carp was slower with a longer half-life period, especially at lower water temperature that was tested.

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278610
Moroxydine hydrochloride, 99%
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