EMAIL THIS PAGE TO A FRIEND

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Discovery of biomarkers for oxidative stress based on cellular metabolomics.


PMID 27168482

Abstract

Oxidative stress has a close relationship with various pathologic physiology phenomena and the potential biomarkers of oxidative stress may provide evidence for clinical diagnosis or disease prevention. Metabolomics was employed to identify the potential biomarkers of oxidative stress. High-performance liquid chromatography-diode array detector, mass spectrometry and partial least squares discriminate analysis were used in this study. The 10, 15 and 13 metabolites were considered to discriminate the model group, vitamin E-treated group and l-glutathione-treated group, respectively. Some of them have been identified, namely, malic acid, vitamin C, reduced glutathione and tryptophan. Identification of other potential biomarkers should be conducted and their physiological significance also needs to be elaborated.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

47863
L-Ascorbic acid, analytical standard
C6H8O6