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Journal of chromatography

Isolation, characterization and determination of trace organic impurities in FD&C red no. 40.


PMID 2753932

Abstract

The unsulfonated aromatic amine 4-nitro-p-cresidine (2-methoxy-5-methyl-4-nitrobenzenamine) was identified as an impurity in the regulated color additive FD&C Red. No. 40. The compound was isolated from the water-soluble color by extraction with chloroform, followed by transfer of the free amines to acid solution and subsequent separation by reversed-phase high-performance liquid chromatography. The 4-nitro-p-cresidine was collected and then identified by gas chromatography-mass spectrometry. The levels of 4-nitro-p-cresidine as well as p-cresidine and aniline were determined in commercial batches of FD&C Red. No. 40.

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