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Scientific reports

Design of a (15)N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State.


PMID 28067292

Abstract

Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [(15)N, D14]trimethylphenylammonium (TMPA) has a remarkably long spin-lattice relaxation time (1128 s, 14.1 T, 30 °C, D2O) on its (15)N nuclei and achieves a long retention of the hyperpolarized state. [(15)N, D14]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by (15)N NMR for over 40 min in phophate-buffered saline (H2O, pH 7.4, 37 °C).

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