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Molecular cell

Expanding the CRISPR Toolbox: Targeting RNA with Cas13b.


PMID 28212745

Abstract

In this issue of Molecular Cell, Smargon etxa0al. (2017) unearth Cas13b from type VI-B CRISPR-Cas immune systems and characterize its RNA-guided, RNA-targeting activity, including regulation by the novel co-factors Csx27 and Csx28, as well as non-specific collateral RNA damage.