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Basic research in cardiology

Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure.


PMID 28238121

Abstract

In the failing heart, iNOS is expressed by both macrophages and cardiomyocytes. We hypothesized that inflammatory cell-localized iNOS exacerbates left ventricular (LV) remodeling. Wild-type (WT) C57BL/6 mice underwent total body irradiation and reconstitution with bone marrow from iNOS(-/-) mice (iNOS(-/-)c) or WT mice (WTc). Chimeric mice underwent coronary ligation to induce large infarction and ischemic heart failure (HF), or sham surgery. After 28xa0days, as compared with WTc sham mice, WTc HF mice exhibited significant (pxa0

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