EMAIL THIS PAGE TO A FRIEND

Oncology reports

Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727.


PMID 28350087

Abstract

Paclitaxel induces apoptosis in a variety of cancer cells. However, the mechanism of paclitaxel inducing apoptosis in human esophageal squamous cell carcinomaxa0(ESCC) remains to be defined. In this study, we found that paclitaxel-induced apoptosis by increasing the relevant apoptosis protein expression and the release of cytochromexa0c via downregulation of signal transducer and activator of transcriptionxa03xa0(STAT3) and phospho-STAT3xa0(Ser727). Inxa0addition, paclitaxel treatment of ESCC cells EC-1 and Eca-109 led to marked mitochondrial membrane potential depolarization and significantly increasing of reactive oxygen species. Moreover, paclitaxel treatment resulted in the inhibition of mitochondrial respiration. Inxa0conclusion, our findings reveal that paclitaxel induced apoptosis in both EC-1 and Eca-109xa0cells through the reduction of STAT3 and phospho‑STAT3xa0(Ser727) level, and suggest that paclitaxel may be of therapeutic potential in the treatment of ESCC through the induction of mitochondrial apoptosis in ESCCxa0cells.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

EHU122051 MISSION® esiRNA, esiRNA human STAT3 (esiRNA1)