EMAIL THIS PAGE TO A FRIEND

The Journal of emergency medicine

Chlorambucil overdose: accidental ingestion of an antineoplastic drug.


PMID 3065402

Abstract

A 22-month-old, 10 kg child ingested 32 mg of chlorambucil and developed irritability, myoclonic-like muscle jerks, an exaggerated startle reflex, vomiting, and EEG changes within a few hours. The neurologic symptoms improved overnight, and the patient was discharged at about 28 hours postingestion. During the three weeks of follow-up, mild bone marrow suppression occurred and resolved. A normal EEG was reported at 33 weeks postingestion.