EMAIL THIS PAGE TO A FRIEND

Biochemical and biophysical research communications

Isolation and primary structure of human peptide YY.


PMID 3202875

Abstract

The isolation, primary structure and chemical synthesis of human peptide YY (PYY) are described. The peptide was purified from human colonic extracts using a chemical method which detected the C-terminal tyrosine amide structure of PYY. Human PYY consists of 36 amino acid residues and the complete amino acid sequence is: Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu- Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu- Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2. The differences between the structures of porcine and human PYY are at positions 3 (Ala/Ile replacement) and 18 (Ser/Asn). Synthetic human PYY prepared using a solid-phase synthetic technique was found to be structurally identical to the natural peptide.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

P1306 Peptide YY human, ≥97% (HPLC), synthetic
C194H295N55O57
P5801 Peptide YY porcine, ≥97% (HPLC), synthetic
C190H288N54O57